Peter W. Atkinson, a University of California, Riverside professor of entomology and member of the university’s Institute for Integrative Genome Biology, is part of a team that has linked the movement of small pieces of DNA, known as transposable elements, to a process called V(D)J recombination that produces the genetic diversity responsible for the production of antibodies. This will help scientists understand the mixing and matching of DNA in organisms and the role this mixing plays in healthy and diseased cells.
Nancy L. Craig from the Howard Hughes Medical Institute and Department of Molecular Biology & Genetics at Johns Hopkins Medical Institute led the team, which published its findings in this week’s issue of the journal Nature, in a paper titled Transposition of hAT elements links transposable elements and V(D)J recombination. Also on the team were Liqin Zhou and Rupak Mitra from Johns Hopkins, and Alison Burgess Hickman and Fred Dyda from the Laboratory of Molecular Biology at the National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Md.
“These functional and comparative studies link the movement of transposable elements and V(D)J recombination. This outcome has implications for understanding transposable element movement in all organisms as well as the role that transpositional type recombination mechanisms have in chromosomal rearrangements of both healthy and diseased cells,” Atkinson said. “Of growing interest is the role that some of these rearrangements may play in the genesis of some cancers.”
Ricardo Duran | EurekAlert!
Nonstop Tranport of Cargo in Nanomachines
20.11.2018 | Max-Planck-Institut für molekulare Zellbiologie und Genetik
Researchers find social cultures in chimpanzees
20.11.2018 | Universität Leipzig
Max Planck researchers revel the nano-structure of molecular trains and the reason for smooth transport in cellular antennas.
Moving around, sensing the extracellular environment, and signaling to other cells are important for a cell to function properly. Responsible for those tasks...
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
19.11.2018 | Event News
09.11.2018 | Event News
06.11.2018 | Event News
20.11.2018 | Life Sciences
20.11.2018 | Life Sciences
20.11.2018 | Physics and Astronomy