The discovery of a new compound by Michigan State University researchers could lead to improved chemotherapy treatments for different types of cancers – potentially with fewer side effects.
The discovery of the compound – known as SP-4-84 – was made by an MSU team led by Jetze Tepe, an assistant professor of chemistry, and is detailed in the December issue of the journal Chemistry & Biology. The researchers believe that the compound, when used in conjunction with chemotherapy drugs such as cisplatin and camptothecin, can make the anti-cancer drugs much more effective. “This may potentially mean that one could use less than one-tenth of the current drug dosage and still get the same therapeutic results – but fewer side effects – or use the same drug dosage which is now much more effective in its treatment,” Tepe said.
Even though this new compound is in the earliest stage of development, this is potentially good news for the millions of Americans diagnosed with cancer every year. The national Centers for Disease Control and Prevention says more than a half-million Americans die of cancer every year, second only to heart disease. Here is how the newly discovered compound works: Most anti-cancer drugs work by causing cell damage, such as DNA damage, which ultimately kills the cancer cells. However, cancer cells are also prone to repair themselves and survive the damage done by drugs, which renders the drugs less effective.
Tom Oswald | EurekAlert!
Progress in Super-Resolution Microscopy
17.12.2018 | Julius-Maximilians-Universität Würzburg
Communication between neural networks
17.12.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau
Researchers from the University of Basel have reported a new method that allows the physical state of just a few atoms or molecules within a network to be controlled. It is based on the spontaneous self-organization of molecules into extensive networks with pores about one nanometer in size. In the journal ‘small’, the physicists reported on their investigations, which could be of particular importance for the development of new storage devices.
Around the world, researchers are attempting to shrink data storage devices to achieve as large a storage capacity in as small a space as possible. In almost...
The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.
Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...
What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...
A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.
The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...
A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.
Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...
12.12.2018 | Event News
10.12.2018 | Event News
06.12.2018 | Event News
17.12.2018 | Studies and Analyses
17.12.2018 | Life Sciences
17.12.2018 | Power and Electrical Engineering