Carbohydrates displayed on the surface of cells play critical roles in cell-cell recognition, adhesion, signaling between cells, and as markers for disease progression. Neural cells for instance use carbohydrates to facilitate development and regeneration and viruses recognize carbohydrates to gain entry into host cells. Identification of the specific saccharides involved in these processes is important to better understand cell-cell recognition at the molecular level and to aid the design of therapeutics and diagnostic tools.
Testing the interaction between bacteria and carbohydrates
So-called microarrays have proven to be a versatile technique in biology, chemistry and medicine to rapidly asses the interactions of ligands and analytes. Researchers of the Laboratory of Organic Chemistry have demonstrated that interactions of bacteria to carbohydrates can also be probed in a microarray format. These results published in the current issue of the scientific magazine “Chemistry & Biology” suggest that microarrays are a general platform to study the carbohydrate-cell interactions. The researchers have also expanded the scope of these methods to include the detection of pathogens within complex mixtures, e.g. blood. Pathogens captured by the arrays can be cultured and further tested for antibacterial susceptibility. It is likely that these assays will allow for rapid screening and testing of pathogens and in uncovering new roles for carbohydrates in cellular biology.
During HIV infection, antibody can block B cells from fighting pathogens
14.08.2018 | NIH/National Institute of Allergy and Infectious Diseases
First study on physical properties of giant cancer cells may inform new treatments
14.08.2018 | Brown University
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur
What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...
The quality of materials often depends on the manufacturing process. In casting and welding, for example, the rate at which melts solidify and the resulting microstructure of the alloy is important. With metallic foams as well, it depends on exactly how the foaming process takes place. To understand these processes fully requires fast sensing capability. The fastest 3D tomographic images to date have now been achieved at the BESSY II X-ray source operated by the Helmholtz-Zentrum Berlin.
Dr. Francisco Garcia-Moreno and his team have designed a turntable that rotates ultra-stably about its axis at a constant rotational speed. This really depends...
08.08.2018 | Event News
27.07.2018 | Event News
25.07.2018 | Event News
14.08.2018 | Information Technology
14.08.2018 | Life Sciences
14.08.2018 | Life Sciences