Inhibiting Apolipoprotein E possible means of therapeutic intervention for Alzheimers disease
A research team led by University of South Florida neuroscientist Huntington Potter, PhD, CEO of the Johnnie B. Byrd Sr. Alzheimers Center & Research Institute, for the first time has defined how the protein Apolipoprotein E (ApoE) contributes to both the formation of amyloid brain lesions and the memory loss associated with Alzheimers disease. The research, conducted jointly by USF and the Byrd Institute, is published in the October 2004 issues of the Journal of Alzheimers Disease and the Neurobiology of Aging.
Previous work has shown that the inflammatory protein ApoE can speed the buildup in the brain of amyloid plaques, the major pathological hallmark of Alzheimers disease. These deposits of plaques are composed primarily of the amyloid-beta protein (AB). However, the mechanism by which ApoE exerted its ill effects on Alzheimers disease was unclear.
Anne DeLotto Baier | EurekAlert!
Microscope measures muscle weakness
16.11.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
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16.11.2018 | Life Sciences
16.11.2018 | Life Sciences