Researchers at the University of Minnesota Stem Cell Institute are one step closer to understanding how blood cells develop through the use of human embryonic stem cells. The research better defines the conditions under which blood cell development occurs, making the process easier to replicate. The findings are published in the October issue of Experimental Hematology.
"These findings do more than give us a basic understanding of blood cell replacement--they allow us to consider potential future therapies," said Dan Kaufman, M.D., assistant professor of medicine in the division of hematology, oncology and lead researcher. "We can envision blood therapies completely compatible with the patient, such as use of embryonic stem cells to make red blood cells for platelets used in blood transfusions, or a source of new blood supply free of any viruses. They might also be a source for bone marrow transplants, especially for those patients who do not otherwise have an appropriately matched donor."
This process is also significant because the blood cells were developed without the use of animal serum, which was previously thought to be essential for blood cell development. Instead, specific growth factors are added to guide the cell differentiation. These results are important for potential human application. Animal serum can potentially contaminate findings and create complications for human trials.
Molly Portz | EurekAlert!
Climate Impact Research in Hannover: Small Plants against Large Waves
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First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
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Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
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Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
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Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
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