Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Yale scientists find cooperative RNA switches in nature

08.10.2004


Research at Yale reported in the journal Science identifies a new riboswitch (RNA regulatory sequence) class in bacteria that operates as a rare "ON" switch for genetic regulation of the three proteins in a glycine processing system.



"This seems like something only a biochemist can appreciate, but what it really means is that modern RNA has what it takes to run the complex metabolism of life. It is like what would have been needed in an "RNA World" - or a period in evolution where RNA served a much larger role," said Ronald T. Breaker, professor in the Department of Molecular, Cellular and Developmental Biology at Yale University.

The latest riboswitch is unique because it is the first RNA switch known to have "cooperative binding" to its target, a process that is common in protein enzymes but not usually associated with RNA. It is also surprising that such complex relics of an RNA World are seen in modern organisms.


Breaker and his research team have pioneered the field of riboswitches and reported the existence of nine classes, so far. Earlier this year they reported in the journal Nature on a class of riboswitch that are ribozymes and catalyze their own feedback loop. The work received the highest all time rating of a peer-reviewed scientific paper by the Faculty of 1000, an on-line web resource where top researcher from around the world rank scientific publications

Breaker’s research, testing theories about how life began, led to the synthesis of "RNA switches" that respond to various target compounds, including several molecules of basic metabolism. They speculated that, if an RNA World theory were true, then RNA molecules most likely would make great molecular switches. After creating RNA switches in the lab, including using a process that simulates Darwinian evolution in the test tube, they looked for naturally occurring riboswitches.

Other authors on this paper include Maumita Mandall, Mark Lee, Jeffrey Barrick and Gail Mitchell Emilsson from Yale and Zasha Weinberg and Walter L. Russo from the University of Washington. The work was supported by grants from the National Institutes of Health, the National Science Foundation, the Yale Liver Center and the David and Lucille Packard Foundation.

Janet Rettig Emanuel | EurekAlert!
Further information:
http://www.yale.edu

More articles from Life Sciences:

nachricht Nonstop Tranport of Cargo in Nanomachines
20.11.2018 | Max-Planck-Institut für molekulare Zellbiologie und Genetik

nachricht Researchers find social cultures in chimpanzees
20.11.2018 | Universität Leipzig

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Nonstop Tranport of Cargo in Nanomachines

Max Planck researchers revel the nano-structure of molecular trains and the reason for smooth transport in cellular antennas.

Moving around, sensing the extracellular environment, and signaling to other cells are important for a cell to function properly. Responsible for those tasks...

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Optical Coherence Tomography: German-Japanese Research Alliance hosted Medical Imaging Conference

19.11.2018 | Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

 
Latest News

Nonstop Tranport of Cargo in Nanomachines

20.11.2018 | Life Sciences

Researchers find social cultures in chimpanzees

20.11.2018 | Life Sciences

When AI and optoelectronics meet: Researchers take control of light properties

20.11.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>