Hotspots in two areas of a gene that encodes a specific signaling enzyme, or kinase, are vulnerable to a variety of mutations found in five types of brain cancers, according to a report published in the August 1 issue of the journal Cancer Research.
Mutations in the gene PIK3CA occur spontaneously as part of the brain tumor development rather than being passed genetically between generations, said Hai Yan, M.D., Ph.D., the senior scientist of the studies conducted by a collaborative research team from Duke University, Johns Hopkins University, and the University of Utah.
"PIK3CA mutations are known to occur in as much as 30 percent of colorectal and gastric cancers and glioblastomas and they are also present, to a lesser extent, in breast and lung cancer," Yan noted. "Our studies defined the association of mutant PIK3CA gene in a wider spectrum of adult and pediatric brain tumors as well."
Russell Vanderboom, PhD | EurekAlert!
Fish recognize their prey by electric colors
13.11.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
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13.11.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
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On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
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Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly
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