Results of laboratory experiments by Johns Hopkins scientists suggest it may be possible to "educate" the immune system to recognize rather than destroy human embryonic stem cells. Doing so could reduce the risk of rejection if the primitive cells are someday transplanted into people with conditions like Parkinson’s disease, diabetes or spinal cord injuries, the researchers say.
In their experiments, described in the July 10 issue of The Lancet, the Hopkins team successfully coaxed human embryonic stem cells to become the special "flag-waving" cells that tell the immune system what is "friend" and what is "foe." In additional experiments in the lab, the researchers found that these so-called antigen presenting cells can control the responses of other immune cells, called T cells, whose job is either to attack or to co-exist with "foreign" cells.
"This is the first evidence that human embryonic stem cells can generate antigen presenting cells that could be used to educate a patient’s immune system," says Linzhao Cheng, Ph.D., assistant professor in Johns Hopkins’ Institute for Cell Engineering. "It’s a small but important step toward future clinical use of the stem cells, but many challenges remain."
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Plant biologists identify mechanism behind transition from insect to wind pollination
18.12.2018 | University of Toronto
Researchers from the University of Basel have reported a new method that allows the physical state of just a few atoms or molecules within a network to be controlled. It is based on the spontaneous self-organization of molecules into extensive networks with pores about one nanometer in size. In the journal ‘small’, the physicists reported on their investigations, which could be of particular importance for the development of new storage devices.
Around the world, researchers are attempting to shrink data storage devices to achieve as large a storage capacity in as small a space as possible. In almost...
The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.
Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...
What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...
A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.
The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...
A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.
Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...
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18.12.2018 | Materials Sciences
18.12.2018 | Physics and Astronomy
18.12.2018 | Physics and Astronomy