Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Evidence of nanobacterial-like structures found in human calcified arteries and cardiac valves

25.05.2004


Evidence could indicate bacteria-like etiology of vascular calcification



Researchers at the Mayo Clinic found they could isolate and culture nanoparticles from filtered homogenates of diseased calcified human cardiovascular tissue. These cultured nano-sized particles were recognized by a DNA-specific dye, incorporated radiolabeled uridine, and after decalcification, appeared via electron microscopy to contain cell walls.

The research paper, entitled "Evidence of Nanobacterial-like Structures in Human Calcified Arteries and Cardiac Valves," has been peer-reviewed and is scheduled for publication in the September 2004 issue of the American Journal of Physiology: Heart and Circulatory Physiology, published by the American Physiological Society. It is currently available online from APS as an Articles in PresS (see below for details).


Noting that the "biological nature of nanometer-sized particles remains controversial," the researchers said their current study "provides anatomical evidence that calcified human arterial and valvular tissue contain nanometer-sized particles which share characteristics of nanoparticles recovered from geological specimens, mammalian blood, and human kidney stones, and observed by transmission electron microscopy in a calcified human mitral valve."

Furthermore, they said they designed their study to systematically replicate earlier work conducted on nanoparticles isolated from human kidney stone using different, but rigorous techniques. They point out that what is recovered from diseased calcified tissue replicates in culture, but that they have not yet been able to identify or label what they have found as nanobacteria described by a unique DNA sequence.

However, they cite evidence that the cultured particles contain nucleic acids because compared to controls containing hydroxyapetite crystals they "incorporated radiolabeled uridine in a time-dependent manner of three days, providing evidence of ongoing nucleic acid synthesis."

One interpretation of these results, especially given such potential parallels as H. pylori causing ulcers, could be that "objects hypothesized to be a type of bacteria (nanobacteria)" could be involved in "mechanisms mediating vascular calcification (which) remain incompletely understood."

Researchers

"Evidence of Nanobacterial-like Structures in Human Calcified Arteries and Cardiac Valves," was carried out by Virginia M. Miller (Mayo Clinic, Rochester, MN), George Rodgers (Heart Hospital, Austin, TX), Jon A. Charlesworth (Mayo), Brenda Kirkland (University of Texas, Austin), Sandra R. Severson (Mayo), Todd E. Rasmussen (Mayo), Marineh Yagubyan (Mayo), Jeri C. Rodgers (U. Texas), Ranklin R. Cockerill III (Mayo), Robert L. Folk (U. Texas), Vivek Kumar (Mayo), Gerard Farell-Baril (Mayo) and John C. Lieske (Mayo).

Mayer Resnick | EurekAlert!
Further information:
http://www.the-aps.org
http://ajpheart.physiology.org/cgi/content/abstract/00075.2004v1

More articles from Life Sciences:

nachricht Structure of a mitochondrial ATP synthase
19.11.2019 | Science For Life Laboratory

nachricht Mantis shrimp vs. disco clams: Colorful sea creatures do more than dazzle
19.11.2019 | University of Colorado at Boulder

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Atoms don't like jumping rope

Nanooptical traps are a promising building block for quantum technologies. Austrian and German scientists have now removed an important obstacle to their practical use. They were able to show that a special form of mechanical vibration heats trapped particles in a very short time and knocks them out of the trap.

By controlling individual atoms, quantum properties can be investigated and made usable for technological applications. For about ten years, physicists have...

Im Focus: Images from NJIT's big bear solar observatory peel away layers of a stellar mystery

An international team of scientists, including three researchers from New Jersey Institute of Technology (NJIT), has shed new light on one of the central mysteries of solar physics: how energy from the Sun is transferred to the star's upper atmosphere, heating it to 1 million degrees Fahrenheit and higher in some regions, temperatures that are vastly hotter than the Sun's surface.

With new images from NJIT's Big Bear Solar Observatory (BBSO), the researchers have revealed in groundbreaking, granular detail what appears to be a likely...

Im Focus: New opportunities in additive manufacturing presented

Fraunhofer IFAM Dresden demonstrates manufacturing of copper components

The Fraunhofer Institute for Manufacturing Technology and Advanced Materials IFAM in Dresden has succeeded in using Selective Electron Beam Melting (SEBM) to...

Im Focus: New Pitt research finds carbon nanotubes show a love/hate relationship with water

Carbon nanotubes (CNTs) are valuable for a wide variety of applications. Made of graphene sheets rolled into tubes 10,000 times smaller than a human hair, CNTs have an exceptional strength-to-mass ratio and excellent thermal and electrical properties. These features make them ideal for a range of applications, including supercapacitors, interconnects, adhesives, particle trapping and structural color.

New research reveals even more potential for CNTs: as a coating, they can both repel and hold water in place, a useful property for applications like printing,...

Im Focus: Magnets for the second dimension

If you've ever tried to put several really strong, small cube magnets right next to each other on a magnetic board, you'll know that you just can't do it. What happens is that the magnets always arrange themselves in a column sticking out vertically from the magnetic board. Moreover, it's almost impossible to join several rows of these magnets together to form a flat surface. That's because magnets are dipolar. Equal poles repel each other, with the north pole of one magnet always attaching itself to the south pole of another and vice versa. This explains why they form a column with all the magnets aligned the same way.

Now, scientists at ETH Zurich have managed to create magnetic building blocks in the shape of cubes that - for the first time ever - can be joined together to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

First International Conference on Agrophotovoltaics in August 2020

15.11.2019 | Event News

Laser Symposium on Electromobility in Aachen: trends for the mobility revolution

15.11.2019 | Event News

High entropy alloys for hot turbines and tireless metal-forming presses

05.11.2019 | Event News

 
Latest News

Structure of a mitochondrial ATP synthase

19.11.2019 | Life Sciences

The measurements of the expansion of the universe don't add up

19.11.2019 | Physics and Astronomy

Ayahuasca compound changes brainwaves to vivid 'waking-dream' state

19.11.2019 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>