Johns Hopkins scientists report that restricting the shape and personal space of human stem cells from bone marrow is more important than any known molecular signal in determining the cell type they become.
Understanding the signals that tell stem cells what type of cell to become, and then harnessing those cues to get a single desired cell type, is key to any effort to use these or more primitive embryonic stem cells to regenerate or repair damaged tissue.
In the April issue of Developmental Cell, the Hopkins researchers report that mesenchymal (pronounced mez-EHN-kih-mal) stem cells forced to be spherical efficiently transform into precursors to fat cells, while those allowed to stretch and flatten move closer to becoming bone cells. These stem cells can naturally become fat cells, cartilage, bone cells, or smooth, cardiac or skeletal muscle.
Joanna Downer | EurekAlert!
Magic number colloidal clusters
13.12.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Record levels of mercury released by thawing permafrost in Canadian Arctic
13.12.2018 | University of Alberta
What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...
A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.
The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...
A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.
Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...
Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...
What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.
Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...
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