Common scientific wisdom is that inherited disease results when a mutated protein communicates a defective message in the cell. That does not explain how similar mutations in proteins result in different severities of diseases.
The answer may be found in the messenger RNA (ribonucleic acid), said Dr. James Lupski, professor of molecular and human genetics and pediatrics at Baylor College of Medicine and colleagues in a report that appears online in Nature Genetics on March 8, 2004.
The stability of the messenger RNA is critical. Aberrant forms of messenger RNA are usually eliminated by a mechanism called nonsense-mediated decay. In some mutations, messenger RNA will be affected by the decay mechanism but in others, it escapes it and causes fabrication of a defective protein. In general, when the mutated RNA falls victim to the decay mechanism, the disease is usually milder than when it escapes it all together.
Lori Williams | EurekAlert!
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In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.
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The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
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