With the full sequence of the human genome now in hand, scientists are turning renewed attention to the molecular processes that regulate the genes encoded by DNA. Estimates are that only a tenth of all genes are expressed at any given time. What controls when and where genes are activated?
Increasingly, researchers believe that the mechanisms that govern gene activity themselves resemble a complicated non-DNA code – an intricate pattern of activity among the molecules that package and control access to the DNA. They suspect that the coordinated interplay of a number of specific enzymes is required to turn on a particular gene.
Now, in a new study using the techniques of structural biology, investigators at The Wistar Institute have shown in detail how two enzymes work together to activate a specific gene by loosening, at that genes location, the compact coils of DNA and packaging proteins called chromatin. The findings bolster the emerging theory that something like a code is responsible for orchestrating genetic activity. A report on the research appears in the August issue of Molecular Cell, published August 28.
Franklin Hoke | EurekAlert!
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25.03.2019 | Albert-Ludwigs-Universität Freiburg im Breisgau
Key evidence associating hydrophobicity with effective acid catalysis
25.03.2019 | Tokyo Metropolitan University
DESY and MPSD scientists create high-order harmonics from solids with controlled polarization states, taking advantage of both crystal symmetry and attosecond electronic dynamics. The newly demonstrated technique might find intriguing applications in petahertz electronics and for spectroscopic studies of novel quantum materials.
The nonlinear process of high-order harmonic generation (HHG) in gases is one of the cornerstones of attosecond science (an attosecond is a billionth of a...
Nano- and microtechnology are promising candidates not only for medical applications such as drug delivery but also for the creation of little robots or flexible integrated sensors. Scientists from the Max Planck Institute for Polymer Research (MPI-P) have created magnetic microparticles, with a newly developed method, that could pave the way for building micro-motors or guiding drugs in the human body to a target, like a tumor. The preparation of such structures as well as their remote-control can be regulated using magnetic fields and therefore can find application in an array of domains.
The magnetic properties of a material control how this material responds to the presence of a magnetic field. Iron oxide is the main component of rust but also...
Due to the special arrangement of its molecules, a new coating made of corn starch is able to repair small scratches by itself through heat: The cross-linking via ring-shaped molecules makes the material mobile, so that it compensates for the scratches and these disappear again.
Superficial micro-scratches on the car body or on other high-gloss surfaces are harmless, but annoying. Especially in the luxury segment such surfaces are...
The Potsdam Echelle Polarimetric and Spectroscopic Instrument (PEPSI) at the Large Binocular Telescope (LBT) in Arizona released its first image of the surface magnetic field of another star. In a paper in the European journal Astronomy & Astrophysics, the PEPSI team presents a Zeeman- Doppler-Image of the surface of the magnetically active star II Pegasi.
A special technique allows astronomers to resolve the surfaces of faraway stars. Those are otherwise only seen as point sources, even in the largest telescopes...
Researchers at Chalmers University of Technology and the University of Gothenburg, Sweden, have proposed a way to create a completely new source of radiation. Ultra-intense light pulses consist of the motion of a single wave and can be described as a tsunami of light. The strong wave can be used to study interactions between matter and light in a unique way. Their research is now published in the scientific journal Physical Review Letters.
"This source of radiation lets us look at reality through a new angle - it is like twisting a mirror and discovering something completely different," says...
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