Proteins, it appears, have taken Frank Sinatras "I Did It My Way" close to heart. A new study published in the current issue of Proceedings of the National Academy of Sciences (PNAS) reveals how single proteins, each a few nanometers (billionths of a meter) long, fold to assume their final shape. It shows that even proteins having the same final shape achieve it by taking different routes.
Proteins are the fundamental components of all living cells. They start out as randomly shaped chains of amino acids and twist into a well-defined three-dimensional structure that determines their function. When this process goes awry, it can result in a wide variety of disorders, including some cancers.
For decades, scientists have pondered how proteins fold. The answer, it was long believed, could be obtained only through watching the folding process of individual proteins. Yet this presented a huge challenge since proteins are extremely small and constantly on the go.
Alex Smith | EurekAlert!
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In living cells, enzymes drive biochemical metabolic processes enabling reactions to take place efficiently. It is this very ability which allows them to be used as catalysts in biotechnology, for example to create chemical products such as pharmaceutics. Researchers now identified an enzyme that, when illuminated with blue light, becomes catalytically active and initiates a reaction that was previously unknown in enzymatics. The study was published in "Nature Communications".
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Early detection of tumors is extremely important in treating cancer. A new technique developed by researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from normal tissue. The work is published May 25 in the journal Nature Nanotechnology.
researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from...
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