Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers Confirm Benzene-like Electron Delocalization

23.06.2008
Researchers in the lab of University of Oregon chemist Shih-Yuan Liu have successfully synthesized and structurally characterized boron-nitrogen compounds that are isoelectronic and isostructural to the fundamentally important benzene molecule.

Given the appearance of benzene derivatives in biomedical research and materials science, the boron-nitrogen substituted analogues could potentially play a pivotal role in these areas.

In the Journal of the American Chemical Society, Liu's team reports that, by using a structural approach, benzene surrogates known as 1,2-dihydro-1,2-azaborines possess electron-delocalized structures consistent with aromaticity -- a core concept in chemistry. The paper already has drawn praise by other researchers in a story in this week's Chemical & Engineering News.

"The bottom line is that we have synthesized reference compounds designed to be non-aromatic, and through the comparisons of the aromatic molecule with the reference compounds, we were able to unambiguously say that this compound is really electron delocalized in a way consistent with aromaticity," Liu said. "With the results of other research in this field, our findings present a very strong case that 1,2-dihydro-1,2-azaborines are indeed aromatic."

... more about:
»Benzene »Liu

Liu is among molecule-making chemists who are interested in manipulating heterocycles -- ring-like structures that contain various elements in addition to carbon. Aromatic heterocycles play a big role in pharmaceuticals, Liu said, noting that eight of the top ten selling molecules on the market today contain aromatic compounds.

For biomedical purposes, Liu said, boron-containing molecules disguised with other components readily accepted by living tissues could conceivably be used as markers to track the location of the drug. Eventually, he said, targeted drug therapies might deliver very specific tumor-destroying action that leaves healthy cells untouched.

"Our objective is really to first develop the synthetic chemistry of these boron-nitrogen heterocycles, make it accessible to other chemists to study, and ultimately go into applied research to create opportunities in cancer therapies and materials sciences," Liu said. "I believe that we have made substantial progress for expanding the scope of accessible molecules such as this. The methods we have developed here at the University of Oregon are beginning to be quite useful."

Co-authors on the paper were lead author Eric R. Abbey, a doctoral student, and Lev N. Zakharov, director of the X-Ray Diffraction Lab in the UO's Center for Advanced Materials Characterization in Oregon (CAMCOR). The research was funded in part by the National Science Foundation.

About the University of Oregon
The University of Oregon is a world-class teaching and research institution and Oregon's flagship public university. The UO is a member of the Association of American Universities (AAU), an organization made up of 62 of the leading public and private research institutions in the United States and Canada. Membership in the AAU is by invitation only. The University of Oregon is one of only two AAU members in the Pacific Northwest.

Source: Shih-Yuan Liu, assistant professor of chemistry, College of Arts and Sciences, 541-346-5573; lsy@uoregon.edu

Links: Shih-Yuan Liu's faculty page: http://www.uoregon.edu/~chem/liu.html; CAMCOR Web site: http://materialscience.uoregon.edu/Outreach/CAMCOR/About.html; College of Arts and Sciences: http://cas.uoregon.edu/

Jim Barlow | newswise
Further information:
http://www.uoregon.edu/~chem/liu.html

Further reports about: Benzene Liu

More articles from Life Sciences:

nachricht World’s Largest Study on Allergic Rhinitis Reveals new Risk Genes
17.07.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Plant mothers talk to their embryos via the hormone auxin
17.07.2018 | Institute of Science and Technology Austria

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Microscopic trampoline may help create networks of quantum computers

17.07.2018 | Information Technology

In borophene, boundaries are no barrier

17.07.2018 | Materials Sciences

The role of Sodium for the Enhancement of Solar Cells

17.07.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>