Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

"Silent" fungus metabolism awakened for new natural products

02.05.2008
US scientists have re-awakened ‘silent’ metabolic pathways in fungi to reveal a new range of natural products. The research could provide not only a source of new drugs, but a way to “listen to what fungi are saying” to organisms around them.

Fungi produce a wide variety of natural products, including potent toxins – for example, the amanitins, primarily responsible for the toxicity of the death cap fungus – and life-saving drugs such as penicillin. As a result, the genetics of fungi have generated much interest in recent years.

Now, Robert Cichewicz and colleagues at the University of Oklahoma, Norman, US, have shown that metabolic pathways that are normally ‘silent’ can be re-activated to make new compounds, in work published in the Royal Society of Chemistry journal Organic & Biomolecular Chemistry.

Many fungi have a wealth of genes encoding for far more natural products than they actually produce, says Cichewicz. The explanation is thought to be that when fungi do not need certain compounds, they inhibit the transcription of the DNA that codes for the proteins that make them, preventing their biosynthesis.

... more about:
»Cichewicz »DNA »fungi »fungus »natural

Knowing what these mystery compounds are could be very important for the development of new medicines, as well as for helping us to understand the ecological roles that fungi play, claims Cichewicz.

The DNA involved is inhibited by being scrunched up in a globular form called heterochromatin. To activate this DNA and turn on these ‘silent’ natural product pathways, the team decided to treat fungal cultures with small molecules that interfere with the formation of the heterochromatin – allowing the DNA to be transcripted.

To show their idea in action, the researchers took a culture of Cladosporium cladosporioides, a tidal pool fungus, and treated it separately with 5-azacytidine and suberoylanilide hydroxamic acid. Both treatments, says Cichewicz, dramatically changed the natural product output of the fungus, with two completely new natural products being isolated.

The new approach impresses Jon Clardy at the Harvard Medical School, Boston, US, who says that it could ‘greatly expand the suite of biologically active small molecules obtained from fungi’ and that it ‘capitalises on recent developments in drug discovery to increase the odds of discovering new drugs’.

The results also have important implications for research into fungi and other microorganisms, explains Cichewicz. Natural products are the means by which fungi ‘communicate’ with organisms around them, so we are in essence, he says, ‘discovering chemical means for listening to what fungi are saying’.

Jon Edwards | alfa
Further information:
http://www.rsc.org

Further reports about: Cichewicz DNA fungi fungus natural

More articles from Life Sciences:

nachricht During HIV infection, antibody can block B cells from fighting pathogens
14.08.2018 | NIH/National Institute of Allergy and Infectious Diseases

nachricht First study on physical properties of giant cancer cells may inform new treatments
14.08.2018 | Brown University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

Im Focus: World record: Fastest 3-D tomographic images at BESSY II

The quality of materials often depends on the manufacturing process. In casting and welding, for example, the rate at which melts solidify and the resulting microstructure of the alloy is important. With metallic foams as well, it depends on exactly how the foaming process takes place. To understand these processes fully requires fast sensing capability. The fastest 3D tomographic images to date have now been achieved at the BESSY II X-ray source operated by the Helmholtz-Zentrum Berlin.

Dr. Francisco Garcia-Moreno and his team have designed a turntable that rotates ultra-stably about its axis at a constant rotational speed. This really depends...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

'Building up' stretchable electronics to be as multipurpose as your smartphone

14.08.2018 | Information Technology

During HIV infection, antibody can block B cells from fighting pathogens

14.08.2018 | Life Sciences

First study on physical properties of giant cancer cells may inform new treatments

14.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>