In culture, neural stem cells (NSCs) can readily differentiate into neuronal and glial subtypes, but their ability to differentiate into region-specific neuronal cell types is limited. Dr. Studer and colleagues isolated and cloned a population of neural rosette cells (R-NSCs), which have an expanded neuronal subtype differentiation potential.
Dr. Studer and colleagues demonstrate that R-NSCs can differentiate along both the CNS and PNS lineages, and are capable of in vivo engraftment. Furthermore, the researchers identified biomarkers unique to the R-NSC type, as well as signaling pathways required for the maintenance of the R-NSC type.
“Our data suggest that R-NSCs may represent the first neural cell type capable of recreating the full cellular diversity of the mammalian nervous system. As such, R-NSCs should have a major impact for applications in regenerative medicine and have the potential to become the "embryonic stem cell equivalent" of the nervous system,” explains Dr. Studer.
Heather Cosel | EurekAlert!
Microscope measures muscle weakness
16.11.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
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16.11.2018 | Life Sciences
16.11.2018 | Life Sciences