A medicine is being developed at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) which controls the concentration of oxygen radicals in immune cells, and could revolutionise treatment of inflammatory diseases or even cancer. The ‘NeutroCure’ project has received funding of approximately three million euros from the European Union as part of the Horizon 2020 programme.
Reactive oxygen species (ROS), more commonly known as oxygen radicals, are both a blessing and a curse: in a healthy organism they regulate cell growth, modulate inflammatory processes and help to capture and eliminate pathogens.
In high concentrations, however, ROS damage tissue, cause uncontrolled inflammation and are involved in triggering cancer and autoimmune diseases.
Paradoxically, however, amplifying oxygen radicals can indeed lead to a cure. In order to benefit from this effect in clinical applications, an innovative new medicine is being developed at FAU.
It deliberately increases the concentration of ROS in neutrophils, special cells in the congenital immune system. This can resolve inflammation or boost blood formation, thereby combating the destruction of stem cells in the bone marrow.
The project is being coordinated by Prof. Dr. Andriy Mokhir (Chair of Organic Chemistry II). Department of Medicine 3 – Rheumatology and Immunology at Universitätsklinikum Erlangen (PD Dr. Markus Hoffmann, Prof. Dr. Martin Herrmann and Prof. Dr. Georg Schett) and research institutions in Great Britain, France, Sweden, Spain and the Ukraine are also involved.
A detailed project description from the EU is available from the Cordis research platform.
Prof. Dr. Andriy Mokhir
Phone: + 49 9131 85 65582
Dr. Susanne Langer | idw - Informationsdienst Wissenschaft
Life's clockwork: Scientist shows how molecular engines keep us ticking
14.01.2020 | University of North Carolina Health Care
World Premiere in Zurich: Machine keeps human livers alive for one week outside of the body
14.01.2020 | Universitätsspital Zürich
Researchers from the University Hospital Zurich, ETH Zurich, Wyss Zurich and the University of Zurich have developed a machine that repairs injured human livers and keep them alive outside the body for one week. This breakthrough may increase the number of available organs for transplantation saving many lives of patients with severe liver diseases or cancer.
Until now, livers could be stored safely outside the body for only a few hours. With the novel perfusion technology, livers - and even injured livers - can now...
A balloon-borne scientific instrument designed to study the origin of cosmic rays is taking its second turn high above the continent of Antarctica three and a half weeks after its launch.
SuperTIGER (Super Trans-Iron Galactic Element Recorder) is designed to measure the rare, heavy elements in cosmic rays that hold clues about their origins...
One last time on Earth it has been turned on in France in December 2019. The next time the MOMA laser developed by the Laser Zentrum Hannover e.V. (LZH) is going into operation will be on Mars. The ExoMars rover into which the laser is integrated has now successfully passed the thermal vacuum tests at Airbus in Toulouse, France.
For 18 days the ExoMars rover Rosalind Franklin was subjected to thermal vacuum tests at Airbus. There, it had to withstand strong changes in temperature and...
The Atacama Desert in Chile is the oldest and most arid desert on earth. Organisms living in this area have adapted to the extreme conditions over thousands of years. A research team led by Dr Patrick Jung has now discovered and investigated a previously unknown biocoenosis of lichens, fungi, cyanobacteria and algae. It colonises tiny stones, so-called grit and its need for water is satisfied by fog and dew. These organisms also decompose the rock on and in which they live. The scientists believe that this is how they have shaped the landscape of the Atacama Desert. Their study was published in the renowned scientific journal "Gebiology".
Many desert areas have large black spots in the sand. These spots are mineral deposits, so-called desert varnish. In the Atacama Desert, which can be compared...
For the first time, physicists from the University of Würzburg have successfully converted electrical signals into photons and radiated them in specific directions using a low-footprint optical antenna that is only 800 nanometres in size.
Directional antennas convert electrical signals to radio waves and emit them in a particular direction, allowing increased performance and reduced...
07.01.2020 | Event News
19.12.2019 | Event News
03.12.2019 | Event News
14.01.2020 | Life Sciences
13.01.2020 | Physics and Astronomy
13.01.2020 | Life Sciences