While it has been well established that royal jelly is the diet that makes bees queens, the molecular path from food to queen is still in dispute. However, scientists at Arizona State University, led by Adam Dolezal and Gro Amdam, have helped reconcile some of the conflicts about bee development and the role of insulin pathways and partner proteins. Their article "IIS and TOR nutrient-signaling pathways act via juvenile hormone to influence honey bee cast fate" has been published in the December issue of the Journal of Experimental Biology.
A worker bee (left) and queen bee (right) show the vast differences in development that can occur based upon the food a bee receives during its larval stages. These bees were raised in the laboratory of Gro Amdam at Arizona State Univeristy. Housed in plastic dishes, rather than a bee colony, allowed complete control of their diet, and offered researchers the ability to manipulate their gene expression levels and better identify developmental routes. Credit: Christofer Bang
However, while Dolezal and Amdam's studies showed that they could block queen development, and then rescue it, and clarified the role of IRS in the queen-making process, their work could not resolve the remaining conflict with Kamakura's results.
Taking a new tack, the Amdam group, which also included Navdeep Mutti, Florian Wolschin, and Jasdeep Mutti, and Washington State University scientist Kulvinder Gill, turned to mathematical modeling, combining their results with approaches that analyze potential partner interactions. These models, developed to understand and clarify complex relationships in physics and biology, allowed the ASU researchers to build a model of consensus – explaining how the IRS partner protein could partner to both epidermal growth factor receptor and the insulin receptor. And while the insulin receptor itself may play no role – as Kamakura's findings suggest – Dolezal and Amdam's findings show that the IRS partner protein may in fact be key to a molecular love triangle, interacting with both receptors, and with the bond to epidermal growth factor receptor being the crowning feature in queen development.
Margaret Coulombe | EurekAlert!
New way to look at cell membranes could change the way we study disease
19.11.2018 | University of Oxford
Controlling organ growth with light
19.11.2018 | European Molecular Biology Laboratory
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
19.11.2018 | Event News
09.11.2018 | Event News
06.11.2018 | Event News
19.11.2018 | Materials Sciences
19.11.2018 | Information Technology
19.11.2018 | Life Sciences