For the study, scientists examined 447 stroke and dementia-free people with an average age of 63.
Participants underwent MRI brain scans such as diffusion tensor imaging (DTI), a technique that measures water molecule movements in the brain. They also completed tests that measured verbal memory, word fluency and executive function, the process in the brain that allows for planning, decision making and selection of appropriate behavior.
The study found that higher levels of CRP led to worse performance in executive function. Higher levels of the protein also affected the frontal lobe of the brain, where some motor functions take place. Motor skills, however, were not measured in the study. Other areas of cognition, such as memory and language skills, showed no association with CRP.
Overall, the average time to complete a test of executive function was 85 seconds. Those with the highest levels of CRP took an average of seven seconds longer to complete the test than those with the lowest levels of the protein. The brain changes measured with DTI were equivalent to 12 years of aging for those with the highest levels of CRP compared to those with the lowest levels.
“The use of aspirin and statin drugs as well as physical activity and controlling weight can help lower CRP levels in the body, but our analyses did not consider whether therapy would be effective or not,” said study author Heike Wersching, MD, with the University of Münster in Germany.
The study was supported by the German Research Foundation (DFG), the Volkswagen Foundation, the Marie Curie Research and Training Network-funded by the European Commission, the BMBF-Competence Network Mednet Atrial Fibrillation, BMBF-Research Consortium and the Neuromedical Foundation Münster.
The American Academy of Neurology, an association of more than 22,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as epilepsy, dystonia, migraine, Huntington’s disease, and dementia. For more information about the American Academy of Neurology, visit http://www.aan.com.VIDEO: http://www.youtube.com/AANChannel
Rachel L. Seroka | American Academy of Neurology
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
17.08.2018 | Physics and Astronomy
17.08.2018 | Information Technology
17.08.2018 | Life Sciences