Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Protein identified that can lengthen our life?

01.03.2012
Cells use various methods to break down and recycle worn-out components – autophagy is one of them. In the dissertation she will be defending at Umeå University in Sweden, Karin Håberg shows that the protein SNX18 is required for cells to be able to perform autophagy.

In animal experiments on both simple organisms like fruit flies and in more complex animals like mice, researchers have seen that stimulating autophagy leads to increased longevity. It is still unclear whether these results are directly translatable to humans.


The picture shows cells which synthesizes a green fluorescent protein attached to autophagosomes and visible in a fluorescense microscope. The cell nuclei are coloured blue. In the left picture normal cells are shown, whilst the ones to the right lacks SNX18. The cells without SNX18 have significantly fewer autophagosomes.
Photo: Umeå University

However, there are theories that calorie restriction, which is a relatively well-established way of increasing longevity, induces higher levels of autophagy, which would help delay aging.

Cells metabolize their old proteins and cell organelles by breaking them down in a process called autophagy. The term comes from Greek and means roughly to eat oneself. Autophagy is important in cleaning out defective components that otherwise can damage cells and cause diseases.

Molecules that are to be broken down are enclosed in a membrane vesicle that forms an organelle called an autophagosome. This then merges with a lysosome, a cell organelle containing many different enzymes that are specialized in breaking down biomolecules. The metabolic products can then be recycled by the cells to synthesize new molecules.

Karin Håberg’s studies show that SNX18 binds to and can reshape cell membranes. Her studies of the role played by SNX18 in autophagy showed that when the cells’ production of SNX18 was stopped by RNA interference, the number of autophagosomes declined drastically, thereby inhibiting the autophagy process.

When the cells were manipulated instead to overproduce SNX18, the number of autophagosomes increased. Karin Håberg was also able to demonstrate that it is precisely the capacity to re-model membranes that is the key to SNX18’s function in the formation of autophagosomes. The studies of autophagy were conducted in collaboration with a research team at Oslo University led by Dr. Anne Simonsen.

Karin Håberg can be reached at: phone +46 (0)90-786 64 38;
e-mail karin.haberg@medchem.umu.se
Reference:
Karin Håberg, Department of Medical Biochemistry and Biophysics, dissertation:

Bertil Born | idw
Further information:
http://www.vr.se
http://umu.diva-portal.org/smash/record.jsf?pid=diva2:492174&rvn=2

Further reports about: Protein autophagy cell membrane enzymes levels of autophagy lysosome

More articles from Life Sciences:

nachricht A new view of microscopic interactions
01.07.2020 | University of Missouri-Columbia

nachricht Microscope allows gentle, continuous imaging of light-sensitive corals
01.07.2020 | Marine Biological Laboratory

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: ILA Goes Digital – Automation & Production Technology for Adaptable Aircraft Production

Live event – July 1, 2020 - 11:00 to 11:45 (CET)
"Automation in Aerospace Industry @ Fraunhofer IFAM"

The Fraunhofer Institute for Manufacturing Technology and Advanced Materials IFAM l Stade is presenting its forward-looking R&D portfolio for the first time at...

Im Focus: AI monitoring of laser welding processes - X-ray vision and eavesdropping ensure quality

With an X-ray experiment at the European Synchrotron ESRF in Grenoble (France), Empa researchers were able to demonstrate how well their real-time acoustic monitoring of laser weld seams works. With almost 90 percent reliability, they detected the formation of unwanted pores that impair the quality of weld seams. Thanks to a special evaluation method based on artificial intelligence (AI), the detection process is completed in just 70 milliseconds.

Laser welding is a process suitable for joining metals and thermoplastics. It has become particularly well established in highly automated production, for...

Im Focus: A structural light switch for magnetism

A research team from the Max Planck Institute for the Structure of Dynamics (MPSD) and the University of Oxford has managed to drive a prototypical antiferromagnet into a new magnetic state using terahertz frequency light. Their groundbreaking method produced an effect orders of magnitude larger than previously achieved, and on ultrafast time scales. The team’s work has just been published in Nature Physics.

Magnetic materials have been a mainstay in computing technology due to their ability to permanently store information in their magnetic state. Current...

Im Focus: Virtually Captured

Biomechanical analyses and computer simulations reveal the Venus flytrap snapping mechanisms

The Venus flytrap (Dionaea muscipula) takes only 100 milliseconds to trap its prey. Once their leaves, which have been transformed into snap traps, have...

Im Focus: NASA observes large Saharan dust plume over Atlantic ocean

NASA-NOAA's Suomi NPP satellite observed a huge Saharan dust plume streaming over the North Atlantic Ocean, beginning on June 13. Satellite data showed the dust had spread over 2,000 miles.

At NASA's Goddard Space Flight Center in Greenbelt, Maryland, Colin Seftor, an atmospheric scientist, created an animation of the dust and aerosols from the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Dresden Nexus Conference 2020: Same Time, Virtual Format, Registration Opened

19.05.2020 | Event News

Aachen Machine Tool Colloquium AWK'21 will take place on June 10 and 11, 2021

07.04.2020 | Event News

International Coral Reef Symposium in Bremen Postponed by a Year

06.04.2020 | Event News

 
Latest News

First exposed planetary core discovered

01.07.2020 | Physics and Astronomy

Energy-saving servers: Data storage 2.0

01.07.2020 | Power and Electrical Engineering

Laser takes pictures of electrons in crystals

01.07.2020 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>