Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Protection For Nerve Cells Delivered Through The Nose

24.08.2018

Researchers work on scientific foundation for new forms of therapy in neurodegenerative processes

Protective proteins that mitigate the destruction of nerve cells after a stroke can be administered into the brain through the nose, as Heidelberg University researchers demonstrated using a mouse model.


The team led by Prof. Dr Hilmar Bading at the Interdisciplinary Center for Neurosciences (IZN) is laying the scientific groundwork for new forms of therapy that inhibit degenerative processes in humans. Prof. Bading's team is concentrating on the body's own neuroprotective mechanisms. The most recent results of their work were published in “Molecular Therapy”.

In earlier studies, the Heidelberg researchers showed that brain activity counteracts nerve cell death. “We know that activated nerve cells produce proteins that guard against cell death,” Prof. Bading explains. At the molecular level, the NMDA receptor plays a key role. If these receptors are not located in the nerve cell junctions, or synapses, they can cause massive cell damage and death.

However, the toxic extrasynaptic NMDA receptors and the consequences of their activation can be suppressed. The neurobiologist's research group discovered that the proteins that trigger this suppression, Activin A and SerpinB2, are produced in the nervous system in response to brain activity.

The researchers were particularly interested in how these protective proteins could be administered from the “outside” when their production via activated nerve cells is low, such as after a stroke.

In cooperation with Dr Bettina Buchthal and Ursula Weiß, Prof. Bading was able to demonstrate that nasal administration paves the way for new treatment approaches for neurodegenerative diseases. They verified this concept using a mouse model. According to Hilmar Bading, mice who received this treatment exhibited less brain damage after a stroke in certain regions of the brain.

Thus, the researchers laid the scientific foundation for a simple “nasal spray” that could reduce the disease-related loss of nerve cells. “Unfortunately, it will take many more years before clinical applications in humans are possible. There are a number of testing phases that must be passed before a new compound is approved as a therapeutic drug,” Prof. Bading adds.

The researcher believes that this “non-invasive and extraordinarily simple treatment principle” would be effective not only in cases of acute post-stroke brain damage. It may also help in chronic neurodegenerative diseases associated with increased activation of extrasynaptic NMDA receptors, which includes amyotrophic lateral sclerosis (ALS), Alzheimer's and Huntington's disease.

Contact:
Heidelberg University
Communications and Marketing
Press Office, phone +49 6221 54-2311
presse@rektorat.uni-heidelberg.de

Wissenschaftliche Ansprechpartner:

Prof. Dr. Hilmar Bading
Interdisciplinary Center for Neurosciences
Phone +49 06221 54-8218
bading@nbio.uni-heidelberg.de

Originalpublikation:

B. Buchthal, U. Weiss and H. Bading: Post-injury Nose-to-Brain Delivery of Activin A and SerpinB2 Reduces Brain Damage in a Mouse Stroke Model. Molecular Therapy (published online 23 July 2018), https://doi.org/10.1016/j.ymthe.2018.07.018

Weitere Informationen:

http://www.uni-heidelberg.de/izn/researchgroups/bading
http://www.uni-heidelberg.de/presse/indexnews.en.html

Marietta Fuhrmann-Koch | idw - Informationsdienst Wissenschaft

More articles from Life Sciences:

nachricht The Secret of the Rock Drawings
24.05.2019 | Max-Planck-Institut für Chemie

nachricht Chemical juggling with three particles
24.05.2019 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New studies increase confidence in NASA's measure of Earth's temperature

A new assessment of NASA's record of global temperatures revealed that the agency's estimate of Earth's long-term temperature rise in recent decades is accurate to within less than a tenth of a degree Fahrenheit, providing confidence that past and future research is correctly capturing rising surface temperatures.

The most complete assessment ever of statistical uncertainty within the GISS Surface Temperature Analysis (GISTEMP) data product shows that the annual values...

Im Focus: The geometry of an electron determined for the first time

Physicists at the University of Basel are able to show for the first time how a single electron looks in an artificial atom. A newly developed method enables them to show the probability of an electron being present in a space. This allows improved control of electron spins, which could serve as the smallest information unit in a future quantum computer. The experiments were published in Physical Review Letters and the related theory in Physical Review B.

The spin of an electron is a promising candidate for use as the smallest information unit (qubit) of a quantum computer. Controlling and switching this spin or...

Im Focus: Self-repairing batteries

UTokyo engineers develop a way to create high-capacity long-life batteries

Engineers at the University of Tokyo continually pioneer new ways to improve battery technology. Professor Atsuo Yamada and his team recently developed a...

Im Focus: Quantum Cloud Computing with Self-Check

With a quantum coprocessor in the cloud, physicists from Innsbruck, Austria, open the door to the simulation of previously unsolvable problems in chemistry, materials research or high-energy physics. The research groups led by Rainer Blatt and Peter Zoller report in the journal Nature how they simulated particle physics phenomena on 20 quantum bits and how the quantum simulator self-verified the result for the first time.

Many scientists are currently working on investigating how quantum advantage can be exploited on hardware already available today. Three years ago, physicists...

Im Focus: Accelerating quantum technologies with materials processing at the atomic scale

'Quantum technologies' utilise the unique phenomena of quantum superposition and entanglement to encode and process information, with potentially profound benefits to a wide range of information technologies from communications to sensing and computing.

However a major challenge in developing these technologies is that the quantum phenomena are very fragile, and only a handful of physical systems have been...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

SEMANTiCS 2019 brings together industry leaders and data scientists in Karlsruhe

29.04.2019 | Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

 
Latest News

On Mars, sands shift to a different drum

24.05.2019 | Physics and Astronomy

Piedmont Atlanta first in Georgia to offer new minimally invasive treatment for emphysema

24.05.2019 | Medical Engineering

Chemical juggling with three particles

24.05.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>