Studies in mice have demonstrated that vaccinations with the amyloid beta protein (believed to be a major AD contributor) to produce AƒÒ antibodies can slow disease progression and improve cognitive function, possibly by promoting the destruction of amyloid plaques. Some early human trials have likewise been promising, but had to be halted due to the risk of autoimmune encephalitis.
One way to make Alzheimer's vaccinations safer would be to use a closely-related, but not human, protein as the vaccine, much like cowpox virus is used for smallpox immunizations.
In the August 15 Journal of Biological Chemistry, Robert Friedland and colleagues used this concept on an amyloid-like protein found in potato virus (PVY). They injected PVY into mice followed by monthly boosters for four months. The researchers found that the mice produced strong levels of antibodies that could attach to amyloid beta protein both in both solution and in tissue samples of Alzheimer's patients. And although the levels were lower, mice also developed AƒÒ antibodies if given injections of PVY-infected potato leaf as opposed to purified PVY.
Friedland and colleagues note that potato virus is a fairly common infection that poses no risk to humans (many people have probably eaten PVY infected potatoes). While tests of PVY antibodies will ultimately determine how useful they can be, they may be a promising lead to treating this debilitating disease.
Nick Zagorski | EurekAlert!
Measuring the Effects of Drugs on Cancer Cells
11.07.2018 | Universität Zürich
Genome's gyrations fit right into Rice University model
10.07.2018 | Rice University
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
Sizes and shapes of nuclei with more than 100 protons were so far experimentally inaccessible. Laser spectroscopy is an established technique in measuring fundamental properties of exotic atoms and their nuclei. For the first time, this technique was now extended to precisely measure the optical excitation of atomic levels in the atomic shell of three isotopes of the heavy element nobelium, which contain 102 protons in their nuclei and do not occur naturally. This was reported by an international team lead by scientists from GSI Helmholtzzentrum für Schwerionenforschung.
Nuclei of heavy elements can be produced at minute quantities of a few atoms per second in fusion reactions using powerful particle accelerators. The obtained...
A team headed by the TUM physicists Alexander Holleitner and Reinhard Kienberger has succeeded for the first time in generating ultrashort electric pulses on a chip using metal antennas only a few nanometers in size, then running the signals a few millimeters above the surface and reading them in again a controlled manner. The technology enables the development of new, powerful terahertz components.
Classical electronics allows frequencies up to around 100 gigahertz. Optoelectronics uses electromagnetic phenomena starting at 10 terahertz. This range in...
03.07.2018 | Event News
28.06.2018 | Event News
28.06.2018 | Event News
11.07.2018 | Information Technology
11.07.2018 | Physics and Astronomy
11.07.2018 | Materials Sciences