The antibiotic, named Seraticin™, is derived from the maggot secretions of the common green bottle fly (Lucilia sericata) and scientists hope to develop it into an injection, pill or ointment.
So far, they have purified Seraticin™ and undertaken the study of its structure and the mechanism by which it prevents infection. The next steps will be to complete the identification of the compound and develop a way to synthesise it. It can then be tested on human cells and eventually in clinical trials in order to determine its medical effectiveness and properties as a novel antibiotic.
MRSA infections cause suffering, amputations and death, not to mention the estimated £1 billion cost to the NHS. Between 2002 and 2006, 6,201 deaths in England and Wales involved MRSA and 15,683 deaths in England and Wales involved C. difficile. The rapid rise in antibiotic-resistant bacteria means that scientists urgently need to find a solution.
Using live maggots on infected wounds is an age-old method of tackling infection and they work with amazing speed. It’s not uncommon for someone to suffer from chronic infected wounds for 18 months, despite all sorts of conventional treatment, but when maggots are applied to the same wound they can often begin to clear infection in just a few days. They have even been known to save people from having limbs amputated.
Dr Yolande Harley of Action Medical Research said: “The discovery of a potential new antibiotic is an exciting advance. It could mean a possible novel treatment for people with chronic wounds that are infected with MRSA or other bugs. By developing the pure antibiotic into a formula, such as a cream, it could reduce the contact patients need to have with live maggots to heal wounds. It could also offer a potential treatment, such as an injection or pill, for internal infections like C. difficile.”
Professor Norman Ratcliffe, a principal researcher on the project at Swansea University, said: “It has been a huge team effort to get to this level and I am delighted with our progress; however there is more to do if we are to realise the maximum benefits from this discovery. It takes approximately 20 mugs of maggots to yield just one drop of purified Seraticin™ at present. Thus, the next stage will be to confirm its exact identity using mass spectrometry and nuclear magnetic resonance analyses in order for us to produce this chemically on a larger scale. “
Dr Alun Morgan of ZooBiotic Ltd, based in Wales, that supplied the maggots for the project, said: “Maggots are great little multi-taskers. They produce enzymes that clean wounds, they make a wound more alkaline which may slow bacterial growth and finally they produce a range of antibacterial chemicals that stop the bacteria growing.”
Bethan Evans | alfa
Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY
NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
19.07.2018 | Earth Sciences
19.07.2018 | Power and Electrical Engineering
19.07.2018 | Materials Sciences