Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

MPI and MDC Researchers Make Significant Strides in Identifying Cause of Bacterial Infections

23.04.2009
Several bacterial pathogens use toxins to manipulate human host cells, ultimately disturbing cellular signal transduction. Until now, however, scientists have been able to track down only a few of the proteins that interact with bacterial toxins in infected human cells.

Now, researchers of the Max Planck Institute of Biochemistry in Martinsried and the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch in Germany have identified 39 interaction partners of these toxins, using novel technology which allowed them to screen for large numbers of proteins simultaneously (Cell Host & Microbe, Vol. 5, Issue 4, 397-403)*.

Many bacteria inject toxins into human cells using a secretion system that resembles a molecular syringe. Within the host cell, some of these toxins are activated in such a way that they can manipulate important cellular signaling pathways. In healthy cells, these signals serve to regulate metabolism or cell division, among other things. By manipulating the signals, bacteria can abuse the cell machinery of the human host in order to spread and survive.

Applying a method developed by Professor Matthias Mann of the MPI, the scientists succeeded for the first time in systematically investigating the cellular target sites of the bacterial toxins. "Surprisingly, the toxins are not optimally adapted to the structures of human proteins," Dr. Matthias Selbach of MDC explained. While binding relatively weakly to individual human proteins, they are able to influence several different proteins simultaneously. "A single bacterial toxin seems to function like a master key that can access different host cell proteins in parallel", Dr. Selbach said. "Perhaps it is due to this strategy that bacteria are able to attack very different cells and, thus, to increase their survival chances in the host."

Dr. Selbach hopes that these basic research findings will help to improve the treatment of bacterial infections in the future. Instead of nonspecific antibiotic therapy, new drugs could target the signaling mechanisms which are disrupted by the bacterial toxins.

*Host cell interactome of tyrosine-phosphorylated bacterial proteins

Matthias Selbach1,2, Florian Ernst Paul2, Sabine Brandt3, Patrick Guye4, Oliver Daumke2, Steffen Backert5, Christoph Dehio4, Matthias Mann1

1Max Planck Institute of Biochemistry, Dept. of Proteomics and Signal Transduction, Am Klopferspitz 18, D-82152 Martinsried, Germany
2Max Delbrück Center for Molecular Medicine, Robert-Rössle-Str. 10, D-13092 Berlin, Germany
3Otto-von-Guericke University Magdeburg, Institute for Medical Microbiology, Leipziger Str. 44, D-39120 Magdeburg, Germany
4Biozentrum of the University of Basel, Focal Area Infection Biology, Klingelbergstrasse 70, CH-4056 Basel, Switzerland

5University College Dublin, School of Biomolecular and Biomedical Science, Ardmore House, Dublin-4, Ireland

Barbara Bachtler
Press and Public Affairs
Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch
Robert-Rössle-Straße 10
13125 Berlin, Germany
Phone: +49 (0) 30 94 06 - 38 96
Fax: +49 (0) 30 94 06 - 38 33
e-mail: presse@mdc-berlin.de

Barbara Bachtler | idw
Further information:
http://www.mdc-berlin.de/
http://www.biochem.mpg.de/mann/index.html

More articles from Life Sciences:

nachricht How molecules teeter in a laser field
18.01.2019 | Forschungsverbund Berlin

nachricht Discovery of enhanced bone growth could lead to new treatments for osteoporosis
18.01.2019 | University of California - Los Angeles

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Ten-year anniversary of the Neumayer Station III

The scientific and political community alike stress the importance of German Antarctic research

Joint Press Release from the BMBF and AWI

The Antarctic is a frigid continent south of the Antarctic Circle, where researchers are the only inhabitants. Despite the hostile conditions, here the Alfred...

Im Focus: Ultra ultrasound to transform new tech

World first experiments on sensor that may revolutionise everything from medical devices to unmanned vehicles

The new sensor - capable of detecting vibrations of living cells - may revolutionise everything from medical devices to unmanned vehicles.

Im Focus: Flying Optical Cats for Quantum Communication

Dead and alive at the same time? Researchers at the Max Planck Institute of Quantum Optics have implemented Erwin Schrödinger’s paradoxical gedanken experiment employing an entangled atom-light state.

In 1935 Erwin Schrödinger formulated a thought experiment designed to capture the paradoxical nature of quantum physics. The crucial element of this gedanken...

Im Focus: Nanocellulose for novel implants: Ears from the 3D-printer

Cellulose obtained from wood has amazing material properties. Empa researchers are now equipping the biodegradable material with additional functionalities to produce implants for cartilage diseases using 3D printing.

It all starts with an ear. Empa researcher Michael Hausmann removes the object shaped like a human ear from the 3D printer and explains:

Im Focus: Elucidating the Atomic Mechanism of Superlubricity

The phenomenon of so-called superlubricity is known, but so far the explanation at the atomic level has been missing: for example, how does extremely low friction occur in bearings? Researchers from the Fraunhofer Institutes IWM and IWS jointly deciphered a universal mechanism of superlubricity for certain diamond-like carbon layers in combination with organic lubricants. Based on this knowledge, it is now possible to formulate design rules for supra lubricating layer-lubricant combinations. The results are presented in an article in Nature Communications, volume 10.

One of the most important prerequisites for sustainable and environmentally friendly mobility is minimizing friction. Research and industry have been dedicated...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Our digital society in 2040

16.01.2019 | Event News

11th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Aachen, 3-4 April 2019

14.01.2019 | Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

 
Latest News

Additive manufacturing reflects fundamental metallurgical principles to create materials

18.01.2019 | Materials Sciences

How molecules teeter in a laser field

18.01.2019 | Life Sciences

The cytoskeleton of neurons has been found to be involved in Alzheimer's disease

18.01.2019 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>