Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mapping of the canary genome

04.02.2015

Hormone sensitive gene regulation in seasonal singing birds

Nature lovers are fascinated by the increasing number of singing birds when spring is approaching. Scientists also take advantage of this seasonal phenomenon because they are able to investigate the underlying mechanism, however the evolutionary and molecularbiological background is largely unknown.


Canary song is regulated by hormones.

© MPI f. Ornithology/ S. Seltmann

A team of researchers from the Max Planck Institute for Ornithology in Seewiesen and from the Max Planck Institute for Molecular Genetics in Berlin have now identified the genome of the canary. With these data they were able to decipher the evolution of hormone-sensitive gene regulation in seasonal singing birds.

Canaries have been domesticated since the 15th century and are the descendants of the wild canary that lives on the Azores, Madeira and Canary Islands in the North Atlantic Ocean. Like their wild ancestors, domesticated canaries sing stereotyped songs under long-day (breeding) conditions and more variable songs under short-day (non-breeding) photoperiods.

The canary has become a preferred model to investigate the neurological changes affecting hormone-dependent song. This is because it has a pronounced reproductive season, with seasonal changes in song and steroid hormone concentrations, and a varying degree of brain plasticity between the breeding and the non-breeding season.

A team of researchers from the department of Behavioural Neurobiology around Manfred Gahr at the Max Planck Institute for Ornithology in Seewiesen and from the Sequencing Core Facility under guidance of Bernd Timmermann from the Max Planck Institute for Molecular Genetics in Berlin together with colleagues from Brazil and the UK now have studied how hormone-sensitive gene regulation has evolved in songbirds. The work resulted in the first high quality assembly and annotation of a female canary genome. In birds, females are the ‘heterogametic’ sex (ZW) and therefore the analysed genome sequence contained both types of sex chromosomes, says Heiner Kuhl from the Max Planck Institute for Molecular Genetics.

Whole genome alignments between the canary and already identified genomes throughout the bird taxa showed that on a global scale bird genomes are quite similar. However, differences appeared when comparisons were conducted on a finer scale. For example, at the level of the nucleotide there are considerable species differences, which can impact small genetic sequences, such as steroid hormone receptor binding sites. Such differences in these regions might lead to major differences in gene regulation, even between closely related species, says Carolina Frankl-Vilches from the Max Planck Institute for Ornithology.

Following this global analysis the scientists focused on gene networks that had three characteristics – were showing enrichment or under-representation in the expression profiles of the song control regions HVC and RA, showed seasonality, and were testosterone-sensitive. To verify whether the hormone-sensitive elements among these genes are specific for the canary, they also looked at the genes of the zebra finch because this species did not evolve hormone-sensitive song expression. Among all HVC expressed genes, including the seasonal and testosterone-induced gene pools, many were strictly canary-specific. These analyses reveal specific evolutionary changes in different parts of the song system that control seasonal singing behaviour.

Thus, in the canary, those genes that are sensitive for testosterone and estrogen, and are also involved in the rewiring of neurons, might be crucial for re-differentiation of the underlying neuronal substrate, such as HVC, leading to seasonal song patterning. The present study demonstrates the need for high-quality genome assembly to detect the evolution of genes in comparative studies, says the coordinator of the study, Manfred Gahr from the Max Planck Institute for Ornithology.


Contact
 
Dr. Carolina Frankl-Vilches
Max Planck Institute for Ornithology, Seewiesen
Phone: +49 8157 932-402
Email: frankl@orn.mpg.de

Dr. Bernd Timmermann
Max Planck Institute for Molecular Genetics, Berlin
Phone: +49 30 84131-777
Email: timmerma@molgen.mpg.de

Dr. Stefan Leitner
Max Planck Institute for Ornithology, Seewiesen
Phone: +49 8157 932-421
Fax: +49 8157 932-209
Email: leitner@orn.mpg.de


Original publication
Carolina Frankl-Vilches, Heiner Kuhl, Martin Werber, Sven Klages, Martin Kerick, Antje Bakker, Edivaldo de Oliveira, Christina Reusch, Floriana Capuano, Jakob Vowinckel, Stefan Leitner, Markus Ralser, Bernd Timmermann, Manfred Gahr

Using the canary genome to decipher the evolution of hormone-sensitive gene regulation in seasonal singing birds

Genome Biology, 3 February 2015

Dr. Carolina Frankl-Vilches | Max Planck Institute for Ornithology, Seewiesen
Further information:
http://www.mpg.de/8937193/canary-genome

More articles from Life Sciences:

nachricht Channels for the Supply of Energy
19.11.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau

nachricht Vine Compound Starves Cancer Cells
19.11.2018 | Julius-Maximilians-Universität Würzburg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

How Humans and Machines Navigate Complex Situations

19.11.2018 | Science Education

Finding plastic litter from afar

19.11.2018 | Ecology, The Environment and Conservation

Channels for the Supply of Energy

19.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>