Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Innate Lymphoid Cells Elicit T Cell Responses

19.08.2014

In case of an inflammation the body releases substances that increase the immune defense. During chronic inflammation, this immune response gets out of control and can induce organ damage.

A research group from the Department of Biomedicine at the University and the University Children’s Hospital of Basel now discovered that innate lymphoid cells become activated and induce specific T and B cell responses during inflammation.


Innate lymphoid cells (ILC3s) with internalized antigens (red fluorescent dots).

Illustration: University of Basel, Department of Biomedicine

These lymphoid cells are thus an important target for the treatment of infection and chronic inflammation. The study was recently published in the scientific journal PNAS.

Innate lymphoid cells (ILCs) are immune cells that regulate early immune responses against viruses, bacteria and parasites through the release of soluble factors. These cells can be classified into three subsets that each have various functions. Type 3 ILCs (ILC3s) are in addition essential for the development of lymphoid organs such as lymph nodes and for tissue repair.

... more about:
»Cell »MHC »PNAS »immune »inflammation »lymphoid »responses »signals

ILC3s internalize antigen and induce T cell responses

The research group lead by Prof. Daniela Finke found that ILC3s take up antigens and present these via so-called MHC molecules on their surface. Specific T cells then recognize these antigen-loaded MHC molecules and induce immune responses. The importance of this interaction between ILC3s and T cells for the immune defense was shown in mice that were lacking the MHC molecules on their ILC3s. These animals had severely reduced T and B cell immune responses.

Inflammatory signals activate ILC3s

So far, scientists assumed that ILC3s decreased T cell responses because they were lacking certain additional receptors required for efficient T cell stimulation. The research group of Prof. Finke was able to show for the first time that these important costimulatory receptors are produced by ILC3s when they are activated through inflammatory signals such as the soluble factor IL-1β. Moreover, ILC3s then produce factors that promote T cell responses.

The results of the Basel research team open up new ways for improving immune responses after vaccination and for preventing harmful immune responses for example during chronic inflammation.

Original source
Nicole von Burg, Stéphane Chappaz, Anne Baerenwaldt, Edit Horvath, Somdeb Bose Dasgupta, Devika Ashok, Jean Pieters, Fabienne Tacchini-Cottier, Antonius Rolink, Hans Acha-Orbea, and Daniela Finke
Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses
PNAS; published online 18 August 2014 | doi: 10.1073/pnas.1406908111

Further information
Prof. Dr. Daniela Finke, University of Basel, Department Biomedicine, and University Children’s Hospital Basel, phone: +41 61 695 30 71, email: daniela.finke@unibas.ch

Weitere Informationen:

http://www.pnas.org/content/early/2014/08/15/1406908111.abstract - Abstract

Reto Caluori | Universität Basel

Further reports about: Cell MHC PNAS immune inflammation lymphoid responses signals

More articles from Life Sciences:

nachricht Bioenergy cropland expansion could be as bad for biodiversity as climate change
11.12.2018 | Senckenberg Forschungsinstitut und Naturmuseen

nachricht How glial cells develop in the brain from neural precursor cells
11.12.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Topological material switched off and on for the first time

Key advance for future topological transistors

Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...

Im Focus: Researchers develop method to transfer entire 2D circuits to any smooth surface

What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.

Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...

Im Focus: Three components on one chip

Scientists at the University of Stuttgart and the Karlsruhe Institute of Technology (KIT) succeed in important further development on the way to quantum Computers.

Quantum computers one day should be able to solve certain computing problems much faster than a classical computer. One of the most promising approaches is...

Im Focus: Substitute for rare earth metal oxides

New Project SNAPSTER: Novel luminescent materials by encapsulating phosphorescent metal clusters with organic liquid crystals

Nowadays energy conversion in lighting and optoelectronic devices requires the use of rare earth oxides.

Im Focus: A bit of a stretch... material that thickens as it's pulled

Scientists have discovered the first synthetic material that becomes thicker - at the molecular level - as it is stretched.

Researchers led by Dr Devesh Mistry from the University of Leeds discovered a new non-porous material that has unique and inherent "auxetic" stretching...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

Expert Panel on the Future of HPC in Engineering

03.12.2018 | Event News

 
Latest News

Electronic evidence of non-Fermi liquid behaviors in an iron-based superconductor

11.12.2018 | Physics and Astronomy

Topological material switched off and on for the first time

11.12.2018 | Materials Sciences

NIST's antenna evaluation method could help boost 5G network capacity and cut costs

11.12.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>