The discovery opens up new opportunities for nutrigenomics researchers looking for links between diet and genetics that will optimize health and lower chronic disease risk.
“Practically all genes related to lipid levels in the bloodstream respond to changes in the diet,” says Jose M. Ordovas, PhD, one of five senior authors of the study and director of the Nutrition and Genomics Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (USDA HNRCA).
“With this new knowledge, we are closer to identifying precise dietary recommendations for people at risk for cardiovascular disease. For instance, carriers of a certain variant gene could reduce their risk of disease with a low-cholesterol diet, carriers of another variant gene may benefit from the Mediterranean diet, while a high-fiber diet may be the healthiest option for carriers of yet another variant gene.”
In addition to the 11 new genes, the authors’ findings strengthen the association of 19 previously identified genes with LDL and HDL cholesterol and triglycerides. Ordovas collaborated with 60 authors, led by corresponding author Sekar Kathiresan, MD, of Massachusetts General Hospital, for the study published December 7 online in Nature Genetics December 7. The study is a meta-analysis of over 20,000 subjects in genome-wide association studies of humans in the United States and Europe with The Framingham Heart Study accounting for the largest number of samples.
“Having identified a total of 30 gene variants is a landmark in lipid research,” says Ordovas, also a professor at the Friedman School of Nutrition and Science Policy at Tufts and Tufts University School of Medicine “It suggests people can have multiple variant genes contributing to dyslipidemia, a combination of spiked LDL and triglyceride levels and extremely low HDL-cholesterol signaling cardiovascular disease risk.
“It is possible there are even more variant genes contributing to dyslipidemia, but even larger studies and more complete genomic characterization based on sequencing are necessary to provide a more complete picture, including interactions with dietary components” Ordovas adds.
Ordovas received funding from the National Heart, Lung and Blood Institute and the USDA Agricultural Research Service (ARS).
Kathiresan, S. et al. Nature Genetics. Dec. 7, 2008 (online)."Common variants at 30 loci contribute to polygenic dyslipidemia."
About Tufts University School of Nutrition
The Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy at Tufts University is the only independent school of nutrition in the United States. The school's eight centers, which focus on questions relating to famine, hunger, poverty, and communications, are renowned for the application of scientific research to national and international policy. For two decades, the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University has studied the relationship between good nutrition and good health in aging populations. Tufts research scientists work with federal agencies to establish the USDA Dietary Guidelines, the Dietary Reference Intakes, and other significant public policies.
Andrea Grossman | Newswise Science News
Scientists discover new 'architecture' in corn
21.01.2019 | Louisiana State University
Nuclear actin filaments determine T helper cell function
21.01.2019 | Universitätsklinikum Heidelberg
The scientific and political community alike stress the importance of German Antarctic research
Joint Press Release from the BMBF and AWI
The Antarctic is a frigid continent south of the Antarctic Circle, where researchers are the only inhabitants. Despite the hostile conditions, here the Alfred...
World first experiments on sensor that may revolutionise everything from medical devices to unmanned vehicles
The new sensor - capable of detecting vibrations of living cells - may revolutionise everything from medical devices to unmanned vehicles.
Dead and alive at the same time? Researchers at the Max Planck Institute of Quantum Optics have implemented Erwin Schrödinger’s paradoxical gedanken experiment employing an entangled atom-light state.
In 1935 Erwin Schrödinger formulated a thought experiment designed to capture the paradoxical nature of quantum physics. The crucial element of this gedanken...
Cellulose obtained from wood has amazing material properties. Empa researchers are now equipping the biodegradable material with additional functionalities to produce implants for cartilage diseases using 3D printing.
It all starts with an ear. Empa researcher Michael Hausmann removes the object shaped like a human ear from the 3D printer and explains:
The phenomenon of so-called superlubricity is known, but so far the explanation at the atomic level has been missing: for example, how does extremely low friction occur in bearings? Researchers from the Fraunhofer Institutes IWM and IWS jointly deciphered a universal mechanism of superlubricity for certain diamond-like carbon layers in combination with organic lubricants. Based on this knowledge, it is now possible to formulate design rules for supra lubricating layer-lubricant combinations. The results are presented in an article in Nature Communications, volume 10.
One of the most important prerequisites for sustainable and environmentally friendly mobility is minimizing friction. Research and industry have been dedicated...
16.01.2019 | Event News
14.01.2019 | Event News
12.12.2018 | Event News
21.01.2019 | Life Sciences
21.01.2019 | Physics and Astronomy
21.01.2019 | Life Sciences