In many forms of cancer, the growth of tumors and their ability to spread are stimulated by a mutated gene that codes for a so-called RAS protein. This has led to intensive research into how to block the activity of these proteins.
“RAS proteins exist in all cells, anchored to the inside of the cell membrane, where they regulate cell growth and cell division. The enzyme we are studying helps RAS proteins get anchored to the cell membrane. By blocking this enzyme, we were able to inhibit the binding of RAS proteins to cell membranes and greatly improve the disease symptoms in mice with blood cancer,” says Associate Professor Martin Bergö, who directs research at the Wallberg? Laboratory at the Sahlgrenska Academy.
The research team has developed a genetically modified mouse that produces a mutated and constantly active RAS protein in its bone marrow, where new blood cells are generated. These mice develop a form of leukemia that is similar to a number of forms of blood cancer in humans. The pathogenic bone marrow cells divide uncontrollably, and the normal control of cell growth cannot turn them off. In these mice, the production of the enzyme called ICMT can also be stopped.
“When we inhibited the production of the enzyme, the development of blood cancer declined, and the uncontrolled growth of bone marrow cells was blocked. Another discovery was that normal bone marrow cells were not significantly affected by the ICMT enzyme. The means that future drugs for inhibiting ICMT could specifically target the pathogenic cells and leave normal cells intact. A drub that blocks this enzyme could be an effective future cancer treatment,” says Martin Bergö.
The research team also demonstrated that mice with an aggressive form of lung cancer lived longer and developed considerably smaller tumors when the ICMT enzyme was blocked. But even though the study strongly indicates that ICMT can be an effective target for cancer treatment, the findings now need to be corroborated by other mice with blood cancer and lung cancer, and drugs to inhibit the enzyme need to be produced and tested.
Ulrika Lundin | alfa
Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY
NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation
A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
20.07.2018 | Power and Electrical Engineering
20.07.2018 | Information Technology
20.07.2018 | Materials Sciences