Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Crucial role for molecule in muscle development

05.07.2011
Research led by the University of East Anglia has discovered the crucial role of a molecule in skeletal muscle development.

The finding could have implications in the future for maintenance of healthy muscle or muscle regeneration in certain diseases, for example cancer and neuromuscular conditions such as muscular dystrophy.

The complexity and significance of microRNA molecules has only recently been recognized and they have been implicated in many biological processes, including disease. Until now nothing was known about their role in the development of skeletal muscle, which is pivotal for movement and supports healthy ageing.

Published this week in the journal Proceedings of the National Academy of Sciences (PNAS), the study was carried out by researchers in the School of Biological Sciences at UEA and the Weizmann Institute of Science, in Rehovot, Israel.

They showed that a particular microRNA, called miR-206, is crucial for normal muscle development in the embryo. MiR-206 switches off a gene called Pax3, this in turn allows early stage muscle cells to become more specialised contractile cells needed for muscle to function. The researchers suggest that this regulation is also important in adult muscle stem cells, which differentiate in response to muscle injury or exercise.

Lead author Andrea Münsterberg, professor in developmental biology at UEA, said: "Muscle is vital to our well being, but it can become fragile, for example as we age or through muscle-wasting diseases. Therefore understanding how muscle tissue develops and is maintained is important."

"Discovering how the Pax3 gene is regulated by miR-206 and controls other genes that lead to muscle differentiation is significant. If you control Pax3 you could control when cells become more specialised and take on their unique function. We suggest that what we have learnt about embryo development also applies to adult muscle."

Prof Münsterberg added: "While not the focus of this study, in theory if we could enhance the function of microRNAs in the body we might in the future be able to promote the maintenance of healthy muscle or muscle regeneration in certain diseases."

The study, 'MicroRNA regulation of the paired-box transcription factor Pax3 confers robustness to developmental timing of myogenesis', is published in Proceedings of the National Academy of Sciences (PNAS): www.pnas.org/content/early/recent

Cat Bartman | EurekAlert!
Further information:
http://www.uea.ac.uk
http://www.pnas.org/content/early/recent

More articles from Life Sciences:

nachricht Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover

nachricht First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>