Their findings have been published in the current issue of Science Express, an online publication of selected papers in advance of the print edition of Science, the main journal of the American Association for the Advancement of Science (AAAS).
"Wolbachia are widespread, maternally-transmitted intracellular bacteria that infect most insect species and are able to alter the reproduction of innumerous hosts," said Horacio Frydman, assistant professor of biology at Boston University and the study's principal investigator. "An important aspect of this relationship is that Wolbachia often alter their host's reproductive ability, yet very little is known about how this is achieved." In this paper, PhD student Eva Fast and her colleagues in the Frydman lab describe a study in Drosophila mauritiana that offers insights into the cellular mechanisms through which Wolbachia upregulates egg production by their hosts.
Specifically, the BU team demonstrate that Wolbachia in D. mauritiana have a remarkable tropism for terminal filament and cap cells in the female germline stem cell (GSC) niche (and a similar tropism in hub cells, the male GSC niche). They also show through extensive analysis of proliferation and cell death markers in multiple experiments that infected D. mauritiana have higher rates of GSC division and lower rates of germline cyst death in the germarium relative to uninfected counterparts. Finally, they provide compelling evidence suggesting that Wolbachia affects GSC division through effects on the niche. "Knowledge emerging from this research will be relevant for the basic stem cell biology as well for the development of cell biological strategies for disease control," said Frydman.
About Boston University—Founded in 1839, Boston University is an internationally recognized private research university with more than 30,000 students participating in undergraduate, graduate, and professional programs. As Boston University's largest academic division, the College and Graduate School of Arts & Sciences is the heart of the BU experience with a global reach that enhances the University's reputation for teaching and research.Contact information for the authors:
Patrick Farrell | EurekAlert!
In focus: Peptides, the “little brothers and sisters” of proteins
12.11.2018 | Technische Universität Berlin
How to produce fluorescent nanoparticles for medical applications in a nuclear reactor
09.11.2018 | Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague)
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly
The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...
Scientists developed specially coated nanometer-sized vehicles that can be actively moved through dense tissue like the vitreous of the eye. So far, the transport of nano-vehicles has only been demonstrated in model systems or biological fluids, but not in real tissue. The work was published in the journal Science Advances and constitutes one step further towards nanorobots becoming minimally-invasive tools for precisely delivering medicine to where it is needed.
Researchers of the “Micro, Nano and Molecular Systems” Lab at the Max Planck Institute for Intelligent Systems in Stuttgart, together with an international...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
12.11.2018 | Life Sciences
12.11.2018 | Materials Sciences
12.11.2018 | Physics and Astronomy