Throughout adulthood, stem cells work to replace mature cells lost to turnover, injury or disease. Some of the genes responsible for keeping stem cells active and productive modify the chromatin, the complex combination of DNA and fibers that make up chromosomes.
Researchers from the Sbarro Institute for Cancer Research and Molecular Medicine at Temple University in Philadelphia and the Human Health Foundation in Spoleto, Italy studied the impact of MECP2, one of the chromatin modifier genes whose mutations underlie RETT syndrome, a severe X-linked neurodevelopmental disorder, on mesenchymal stem cells, or MSCs, multipotent stem cells that can differentiate into a variety of cell types. Their findings were published in the Journal of the Federation of American Societies for Experimental Biology.
“Our studies suggest that MECP2 is a factor whose expression must be tightly regulated to avoid alteration in the cell’s function,” said Dr. Umberto Galderisi, Department of Experimental Medicine, Biotechnology and Molecular Biology Section, Second University of Naples, Italy and lead author of the study. “To be specific, its inhibition induces the senescence, or the aging, phenomena in MSCs.”
MSC’s are of particular interest to researchers, because of the multiple roles that they perform. They support hematopoiesis, or blood production, and contribute to the maintenance of many organs and tissues. Their aging has profound consequences on body physiology.
“Studies on in vitro stem cell senescence can be of interest in order to dissect molecular events leading to a decline of stem cell functions with advancing of age,” said Dr. Antonio Giordano, director of the Sbarro Institute and the Center for Biotechnology at Temple University in Philadelphia, PA.
Sbarro Health Research Organization (www.shro.org) funds the Sbarro Institute for Cancer Research and Molecular Medicine, a leading nonprofit research center for cancer, diabetes, and cardiovascular disease. Based in Philadelphia, Pennsylvania on the campus of Temple University, our programs train young scientists from around the globe.
The Human Health Foundation is a nonprofit research foundation devoted to basic medical research and biotechnology located in Spoleto, Italy.
Ilene Rush | Newswise Science News
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
17.08.2018 | Physics and Astronomy
17.08.2018 | Information Technology
17.08.2018 | Life Sciences