A team of NYU physicists has developed a method to monitor the properties of microscopic particles as they grow within a chemical reaction vessel, creating new opportunities to improve the quality and consistency of a wide range of industrial and consumer products. Their work, which appears as a cover story in the journal Soft Matter, offers benefits for commodities ranging from food and pharmaceuticals to perfumes and cosmetics.
“We can now look at each of the particles in a developing dispersion to see how the chemical reaction is progressing and whether the particles are turning out the way they should,” explains NYU Physics Professor David Grier, one of the paper’s authors and director of the university’s Center for Soft Matter Research.
Previously, scientists could not look inside a growing microparticle and understand the nature of the material it was composed of—Is the particle fully dense or is it porous? Are all the particles growing in the same way, or are some different from others?
“In the past, there was no way to know these answers because we could not characterize particles’ makeup,” Grier explains. “Now we can.”
The work reported in Soft Matter relies on a technique, holographic video microscopy, which was developed in Grier’s lab at NYU in 2007. It uses a laser beam to create holographic images of individual particles using conventional video cameras and digital video recorders to record the data.
The researchers novel analysis of these digitized holograms yields an unprecedented wealth of information about the positions and properties of the individual particles within the sample. This information, in turn, reveals how well the reaction is progressing and what steps should be taken to optimize its products.
To demonstrate the capabilities of their technique, the researchers studied the synthesis of crosslinked polydimethysiloxane (PDMS) spheres—compounds that make up silicone.
However, Grier says, the procedure could be applied to particles that comprise many consumer products.
“If a cosmetics company wants to add a new fragrance to its products or a pharmaceutical company needs to change the active ingredients of a drug, they need to add new chemical compounds,” Grier explains. “But how will they interact? How will this change the consistency of the product? And, especially in the case of drug development, will they be effective?
“This procedure shows that we now have the potential understand this process at the most fundamental level, which would enhance both product design and production.”
Holographic characterization provides insights into the properties of products that will enhance their safety, functionality, and consistency, and will reduce costs by improving process control and eliminating the need for trial-and-error testing, Grier says. His group’s proof-of-concept demonstration is being brought to the market by Spheryx, Inc. (http://spheryx.solutions/), which has exclusively licensed NYU’s technology for holographic characterization.
The paper’s other authors are: Chen Wang, a doctoral student in NYU’s Department of Physics; NYU Physics Professor Andrew Hollingsworth; and Hagay Shpaisman, an NYU post-doctoral fellow at the time of the study and now a Senior Lecturer at Israel’s Bar-Ilan University.
The research was supported by grants from Procter & Gamble and NASA (NNX13AR67G) as well as by the National Science Foundation under its MRSEC (DMR-1420073) and MRI (DMR-0923251) programs. The article describing this work is published in Soft Matter, volume 11, pages 1062 – 1066, February 14, 2015.
Deputy Director for Media Relations
James Devitt | newswise
Mechanical engineers develop process to 3D print piezoelectric materials
22.01.2019 | Virginia Tech
Advanced X-ray Topography Tool Offers More Insights into Semiconductor Material Quality
21.01.2019 | Fraunhofer-Gesellschaft
So-called bifacial stem cells are responsible for one of the most critical growth processes on Earth – the formation of wood.
Immune cells called macrophages are supposed to serve and protect, but cancer has found ways to put them to sleep. Now researchers at the Abramson Cancer...
The scientific and political community alike stress the importance of German Antarctic research
Joint Press Release from the BMBF and AWI
The Antarctic is a frigid continent south of the Antarctic Circle, where researchers are the only inhabitants. Despite the hostile conditions, here the Alfred...
World first experiments on sensor that may revolutionise everything from medical devices to unmanned vehicles
The new sensor - capable of detecting vibrations of living cells - may revolutionise everything from medical devices to unmanned vehicles.
Dead and alive at the same time? Researchers at the Max Planck Institute of Quantum Optics have implemented Erwin Schrödinger’s paradoxical gedanken experiment employing an entangled atom-light state.
In 1935 Erwin Schrödinger formulated a thought experiment designed to capture the paradoxical nature of quantum physics. The crucial element of this gedanken...
16.01.2019 | Event News
14.01.2019 | Event News
12.12.2018 | Event News
22.01.2019 | Life Sciences
22.01.2019 | Architecture and Construction
22.01.2019 | Life Sciences