The device, called acoustic tweezers, is the first technology capable of touchlessly trapping and manipulating Caenorhabditis elegans (C. elegans), a one millimeter long roundworm that is an important model system for studying diseases and development in humans. Acoustic tweezers are also capable of precisely manipulating cellular-scale objects that are essential to many areas of fundamental biomedical research.
For many biological systems, acoustic tweezers will provide an excellent tool to mimic the conditions inside the body where cells are subject to waves of pressure and pulses of chemicals. According to Stephen Benkovic, Evan Pugh professor of chemistry and holder of the Eberly family chair in chemistry at Penn State, whose group contributed to the paper, “Acoustic tweezers will be used to position cells for interrogation by pulses of drug-like molecules to test as well as to exert mechanical forces on the cell wall. The cells will contain bio-chemical markers, so we can observe the effect of drug pulses or pressure on the cell’s biochemistry.”
Acoustic tweezers are very versatile, says Huang. “We can manipulate a single cell or we can manipulate tens of thousands of cells at the same time.” Currently, the size of objects that can be moved with acoustic tweezers ranges from micrometers to millimeters, although with higher frequencies, it should be possible to move objects in the nanoscale regime, they believe. Further work will include modifying the device to accommodate more fundamental biomedical studies with the Benkovic group. Ultimately, the patent pending technology could lead to compact, noninvasive, and inexpensive point-of-care applications, such as blood cell and cancer cell sorting and diagnostics. For now, the ability to trap and manipulate a living C. elegans for study is proof of their device’s potential utility.Contributing to the PNAS paper, “On-chip Manipulation of Single Microparticles, Cells, and Organisms Using Surface Acoustic Waves,” are Xiaoyun Ding, Sz-Chin Steven Lin, Brian Kirby, Hongjun Yue, Sixing Li, Jinjie Shi, Stephen J. Benkovic, and Tony Jun Huang. Funding for their research was provided by the National Science Foundation and the National Institutes of Health. To see a short video clip of cell manipulation, visit: http://www.mri.psu.edu/news/2012/acoustic_tweezers_capture_tiny_creatures/
Contacts: Tony Jun Huang at firstname.lastname@example.org, or 814 863-4209. Stephen J. Benkovic at email@example.com
Stephen J. Benkovic | Newswise Science News
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