Prostate Cancer Survival Benefit From A Combination Of Androgen Suppression And External Irradiation

Disease-free survival from advanced prostate cancer could be almost doubled if hormone-suppression therapy is used during and after radiotherapy for a duration of 3 years, suggest authors of an international study in this week’s issue of THE LANCET.

Long-term survival after radiotherapy for people with advanced prostate cancer is poor. Michel Bolla from University Hospital, Grenoble, France, and colleagues investigated the added value of long-term male-hormone (androgen) suppression in locally advanced prostate cancer.

415 patients with advanced prostate cancer were randomly assigned radiotherapy or radiotherapy and immediate androgen suppression. Average follow-up time was five and a half years.

Patients given combined radiotherapy and hormone-suppression therapy had a substantially increased five-year disease-free survival rate (74%) than patients given radiotherapy alone (40%). Overall survival rates were 78% for combined therapy and 62% for radiotherapy alone.

Michel Bolla comments: “androgen suppression provides a means of improving the outcome of external irradiation alone, by possibly eliminating occult disease. Moreover androgen suppression and external irradiation appear to have an additive effect on local disease control by inducing apoptosis [tumour-cell death]”.

Media Contact

Richard Lane alfa

All latest news from the category: Health and Medicine

This subject area encompasses research and studies in the field of human medicine.

Among the wide-ranging list of topics covered here are anesthesiology, anatomy, surgery, human genetics, hygiene and environmental medicine, internal medicine, neurology, pharmacology, physiology, urology and dental medicine.

Back to home

Comments (0)

Write a comment

Newest articles

A world-first antibody-drug delivery system

It sounds like the stuff of science fiction: a man-made crystal that can be attached to antibodies and then supercharge them with potent drugs or imaging agents that can seek…

Revealed: How SARS-CoV-2 evades our immune system

Scientists at Hokkaido University and Texas A&M University have identified a key mechanism used by the SARS-CoV-2 virus to evade host immune systems. Researchers in Japan and the United States…

New approach developed to predict response of immunotherapies in lung cancer

New methodology at the University Hospital of Tübingen harnesses the function of platelets. At Tübingen University Hospital, a preclinical study led by Dr. Clemens Hinterleitner and Prof. Dr. Lars Zender,…

Partners & Sponsors