Toward broad-spectrum antiviral drugs for common cold and other infections
Angus MacLeod and colleagues note that although many HRV infections cause mild disease, they can lead to dangerous complications for millions of people with asthma and chronic obstructive pulmonary disease.
Previous potential drugs for HRV either didn't work or caused unacceptable side effects, leaving only one potential drug still under development in clinical trials. MacLeod's team set out to find new antiviral candidates to meet this serious health challenge.
They describe identifying and successfully testing a group of compounds that work against human rhinovirus, Coxsackie virus, poliovirus and enterovirus-71 — the cause of hand, foot and mouth disease. The substances work by blocking the ability of these viruses to multiply.
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