immature state and is, therefore, inactive. Molecules that interfere specifically in the dicer-pre-miRNA interaction can be used as new tools to modulate gene regulation. The new assay allows the screening for molecules that disrupt the dicer binding to pre-miRNAs.
As miRNAs are regulators in metabolic pathways they are involved also in many diseases. Specific miRNA maturation inhibitors will have the potential to be used as new therapeutic approaches for diseases like cancer, diabetes, or viral infections. The micro RNA maturation assay is based on microtiter plate technology to allow high throughput screening of compound libraries.
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