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miRNA Maturation Assay – Screening Tool for Specific miRNA Maturation Inhibitors

26.05.2009
The micro RNA maturation assay offers the opportunity to screen for small molecules influencing the dicer-mediated maturation process of miRNAs. miRNAs are molecules regulating the expression of around 30% of the human genes. The dicer protein catalyses the last step of maturation from pre-miRNA to active miRNAs. If the binding of the dicer to the individual pre-miRNA is disturbed the miRNA remains in the

immature state and is, therefore, inactive. Molecules that interfere specifically in the dicer-pre-miRNA interaction can be used as new tools to modulate gene regulation. The new assay allows the screening for molecules that disrupt the dicer binding to pre-miRNAs. As miRNAs are regulators in metabolic pathways they are involved also in many diseases. Specific miRNA maturation inhibitors will have the potential to be used as new therapeutic approaches for diseases like cancer, diabetes, or viral infections. The micro RNA maturation assay is based on microtiter plate technology to allow high throughput screening of compound libraries.

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