The complete DNA sequence of the gene cluster coding for the microginin synthetase of the cyanobacterium Microcystis aeruginosa has been identified and sequenced for the first time. The microginin synthetase is a large multi-enzyme complex which catalyzes the microginin, a small linear lipopeptide belonging to the group of non-ribosomal synthesized peptides. <br><br> Microginins are synthesized by various species of cyanobacteria (“blue-green algae”) in diverse structure variants. Mircroginins represent an interesting group of unusual peptides in view of medical application as they are known to have inhibitory effects on the Angiotensin-Converting- Enzyme (ACE). Thus, microginins are potential ACE-inhibitors and represent important drug candidates to treat hypertension and associated diseases such as chronic heart failure and diabetic nephropathy.<br><br>
email@example.com | TechnologieAllianz e.V.
Synthesis of novel Myrtucommulone and Analogues
25.11.2013 | TechnologieAllianz e.V.
Transmission signal separation in radar systems for OFDM and multicarrier radar
22.11.2013 | TechnologieAllianz e.V.
22.10.2014 | Event News
16.10.2014 | Event News
10.10.2014 | Event News
24.10.2014 | Life Sciences
24.10.2014 | Earth Sciences
24.10.2014 | Press release