Muscular dystrophies are a heterogenous group of inherited single-gene disorders, characterized clinically by progressive muscle weakness and wasting. In many cases the molecular basis of a muscular dystrophy is a disruption of the cytoskeleton - extracellular - matrix link, caused by a lack of expression of components of the dystrophin-glycoproteincomplex (DGC).
According to a current model this results in a destabilization of the entire DGC, thereby affecting the structural integrity of the muscle membrane. Duchenne muscular dystrophy (DMD), a severe X-chromosome-linked myopathy, is caused by mutations in the dystrophin gene. Nevertheless, several lines of evidence indicate that dystrophin deficiency is only the first step of a complex pathogenic cascade and much of the late pathology seems to result from ongoing cycles of muscle fiberde- and regeneration. In this respect, characterization of key control components of the de-/regeneration system would open new paths to interfere with the dystrophic process.
Further Information: PDF
Bayerische Patentallianz GmbH
Phone: +49 89 5480177-0
firstname.lastname@example.org | TechnologieAllianz e.V.
New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.
Gratings on glass surfaces
28.03.2017 | TechnologieAllianz e.V.
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
18.08.2017 | Life Sciences
18.08.2017 | Physics and Astronomy
18.08.2017 | Materials Sciences