Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Alcohol Use Marker May Also Signal Marijuana Use, Risk Of Depression

15.07.2002


An enzyme whose activity is affected by alcohol may prove useful in identifying recent alcohol or marijuna use even though it does not seem to be a good marker for genetic predisposition to alcoholism, a new international study finds. The researchers also found that the activity level of the enzyme, adenylyl cyclase, steadily dropped in people who had abstained from drinking for days to weeks and was generally lower in people with a history of major depression, according to the study published in the July issue of Alcoholism: Clinical and Experimental Research.

Previous research has shown an association between a family history of alcoholism and lower activity levels of adenylyl cyclase, says lead author Paula L. Hoffman, Ph.D., of the University of Colorado Health Sciences Center.

This study, which had a much larger sample size than previous research, shows that the effect of genetic susceptibility to alcoholism on this enzyme’s activity levels is lost in the wake of the more substantial influence of recent alcohol use.



The study included nearly 1,500 subjects in five countries. Researchers interviewed and categorized participants as alcohol dependent or alcohol abusers, based on standard criteria. The researchers used blood tests to measure adenylyl cyclase levels along with other markers known to reflect alcohol use.

Adenylyl cyclase activity was more sensitive to alcohol consumption in subjects with a family history of alcoholism than in those without such a genetic susceptibility. However, the activity levels fluctuated so much and proved most sensitive to recent drinking, i.e. in the past week, that it was not a consistent measure for assessing family history.

The researchers also found that adenylyl cyclase activity levels were substantially higher in chronic marijuana users; they suggest this may be a product of marijuana use or an abnormal metabolism in those prone to abusing the drug.

People with a history of major depression were also more likely to have low adenylyl cyclase activity levels, a finding that may point to one genetic factor in depression, the authors say.

This study was conducted as part of the WHO/ISBRA Study on State and Trait Markers of Alcohol Use and Dependence.

Ira R. Allen | EurekAlert
Further information:
http://www.alcoholism-cer.com

More articles from Social Sciences:

nachricht Polluted air may pollute our morality
08.02.2018 | Association for Psychological Science

nachricht Sibling differences: Later-borns choose less prestigious programs at university
14.11.2017 | Max-Planck-Institut für demografische Forschung

All articles from Social Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

Im Focus: Autonomous 3D scanner supports individual manufacturing processes

Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).

Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Fingerprints of quantum entanglement

16.02.2018 | Information Technology

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers

16.02.2018 | Health and Medicine

Hubble sees Neptune's mysterious shrinking storm

16.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>