Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Alcohol Use Marker May Also Signal Marijuana Use, Risk Of Depression

15.07.2002


An enzyme whose activity is affected by alcohol may prove useful in identifying recent alcohol or marijuna use even though it does not seem to be a good marker for genetic predisposition to alcoholism, a new international study finds. The researchers also found that the activity level of the enzyme, adenylyl cyclase, steadily dropped in people who had abstained from drinking for days to weeks and was generally lower in people with a history of major depression, according to the study published in the July issue of Alcoholism: Clinical and Experimental Research.

Previous research has shown an association between a family history of alcoholism and lower activity levels of adenylyl cyclase, says lead author Paula L. Hoffman, Ph.D., of the University of Colorado Health Sciences Center.

This study, which had a much larger sample size than previous research, shows that the effect of genetic susceptibility to alcoholism on this enzyme’s activity levels is lost in the wake of the more substantial influence of recent alcohol use.



The study included nearly 1,500 subjects in five countries. Researchers interviewed and categorized participants as alcohol dependent or alcohol abusers, based on standard criteria. The researchers used blood tests to measure adenylyl cyclase levels along with other markers known to reflect alcohol use.

Adenylyl cyclase activity was more sensitive to alcohol consumption in subjects with a family history of alcoholism than in those without such a genetic susceptibility. However, the activity levels fluctuated so much and proved most sensitive to recent drinking, i.e. in the past week, that it was not a consistent measure for assessing family history.

The researchers also found that adenylyl cyclase activity levels were substantially higher in chronic marijuana users; they suggest this may be a product of marijuana use or an abnormal metabolism in those prone to abusing the drug.

People with a history of major depression were also more likely to have low adenylyl cyclase activity levels, a finding that may point to one genetic factor in depression, the authors say.

This study was conducted as part of the WHO/ISBRA Study on State and Trait Markers of Alcohol Use and Dependence.

Ira R. Allen | EurekAlert
Further information:
http://www.alcoholism-cer.com

More articles from Social Sciences:

nachricht Amazingly flexible: Learning to read in your thirties profoundly transforms the brain
26.05.2017 | Max-Planck-Institut für Kognitions- und Neurowissenschaften

nachricht Fixating on faces
26.01.2017 | California Institute of Technology

All articles from Social Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>