Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Alcohol Use Marker May Also Signal Marijuana Use, Risk Of Depression

15.07.2002


An enzyme whose activity is affected by alcohol may prove useful in identifying recent alcohol or marijuna use even though it does not seem to be a good marker for genetic predisposition to alcoholism, a new international study finds. The researchers also found that the activity level of the enzyme, adenylyl cyclase, steadily dropped in people who had abstained from drinking for days to weeks and was generally lower in people with a history of major depression, according to the study published in the July issue of Alcoholism: Clinical and Experimental Research.

Previous research has shown an association between a family history of alcoholism and lower activity levels of adenylyl cyclase, says lead author Paula L. Hoffman, Ph.D., of the University of Colorado Health Sciences Center.

This study, which had a much larger sample size than previous research, shows that the effect of genetic susceptibility to alcoholism on this enzyme’s activity levels is lost in the wake of the more substantial influence of recent alcohol use.



The study included nearly 1,500 subjects in five countries. Researchers interviewed and categorized participants as alcohol dependent or alcohol abusers, based on standard criteria. The researchers used blood tests to measure adenylyl cyclase levels along with other markers known to reflect alcohol use.

Adenylyl cyclase activity was more sensitive to alcohol consumption in subjects with a family history of alcoholism than in those without such a genetic susceptibility. However, the activity levels fluctuated so much and proved most sensitive to recent drinking, i.e. in the past week, that it was not a consistent measure for assessing family history.

The researchers also found that adenylyl cyclase activity levels were substantially higher in chronic marijuana users; they suggest this may be a product of marijuana use or an abnormal metabolism in those prone to abusing the drug.

People with a history of major depression were also more likely to have low adenylyl cyclase activity levels, a finding that may point to one genetic factor in depression, the authors say.

This study was conducted as part of the WHO/ISBRA Study on State and Trait Markers of Alcohol Use and Dependence.

Ira R. Allen | EurekAlert
Further information:
http://www.alcoholism-cer.com

More articles from Social Sciences:

nachricht Fixating on faces
26.01.2017 | California Institute of Technology

nachricht Internet use in class tied to lower test scores
16.12.2016 | Michigan State University

All articles from Social Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>