Researchers at Oxford University’s Department of Engineering Science have recently made great lengths in both engineering and monitoring 3-dimensional tissue.
Experimental hollow fibre bioreactor.
Engineering tissue involves the seeding of appropriate cells into a scaffold to form a bio-construct or matrix. The Oxford team has improved this process by developing a new kind of nutrient circulation and scaffold system for 3-D bulky tissue culture. The scaffold, made from biopolymers or synthetic polymers, has a network of capillaries embedded within it that can service the cells that attach themselves to the scaffold, allowing new tissue to grow. The capillary network is made of semi-permeable membranes whose pore size is sufficiently small to keep cells from leaving the system.
The unique Oxford system employs biodegradable porous membrane capillaries to mimic the blood capillary network in natural tissue. Traditionally, engineered tissue is governed by the diffusion of nutrients from outside the scaffold, but this system employs a system of capillaries that deliver nutrients and remove metabolic waste deep inside. Additionally, the capillary membrane is biodegradable, meaning that as time progresses the pores will widen, allowing more nutrients in and waste out. The Oxford system not only allows tissue of greater density to be grown, but as the tissue becomes bulkier, epithelial cells can be introduced in to the capillaries to promote blood vessel formation. This invention enables the culture of 3-dimensional tissues opening the possibility of growing more complex structures (such as complete organs).
Jennifer Johnson | alfa
Etching Microstructures with Lasers
25.10.2016 | Fraunhofer-Institut für Lasertechnik ILT
Applying electron beams to 3-D objects
23.09.2016 | Fraunhofer-Institut für Organische Elektronik, Elektronenstrahl- und Plasmatechnik FEP
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
02.12.2016 | Medical Engineering
02.12.2016 | Agricultural and Forestry Science
02.12.2016 | Physics and Astronomy