Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Medical Breakthrough in Engineering and Monitoring 3-D Tissue

13.10.2003


Researchers at Oxford University’s Department of Engineering Science have recently made great lengths in both engineering and monitoring 3-dimensional tissue.


Experimental hollow fibre bioreactor.



Engineering tissue involves the seeding of appropriate cells into a scaffold to form a bio-construct or matrix. The Oxford team has improved this process by developing a new kind of nutrient circulation and scaffold system for 3-D bulky tissue culture. The scaffold, made from biopolymers or synthetic polymers, has a network of capillaries embedded within it that can service the cells that attach themselves to the scaffold, allowing new tissue to grow. The capillary network is made of semi-permeable membranes whose pore size is sufficiently small to keep cells from leaving the system.

The unique Oxford system employs biodegradable porous membrane capillaries to mimic the blood capillary network in natural tissue. Traditionally, engineered tissue is governed by the diffusion of nutrients from outside the scaffold, but this system employs a system of capillaries that deliver nutrients and remove metabolic waste deep inside. Additionally, the capillary membrane is biodegradable, meaning that as time progresses the pores will widen, allowing more nutrients in and waste out. The Oxford system not only allows tissue of greater density to be grown, but as the tissue becomes bulkier, epithelial cells can be introduced in to the capillaries to promote blood vessel formation. This invention enables the culture of 3-dimensional tissues opening the possibility of growing more complex structures (such as complete organs).


Engineered Tissue Probes
To monitor the engineered tissue from the new system, Oxford researchers have also developed a technology for the on-line monitoring of cell metabolic activity, cell viability, function and tissue status.

It is important to monitor cell activity and functions inside three-dimensional engineered tissue during the culture process in vitro in order to optimise the design and operation of the tissue culture process. It is also critical to monitor tissue status following transplant/implant (e.g. tissue grafts and implantation of engineered tissue). Possible techniques at present include MRI and ultrasound, but both are time consuming, expensive, give low resolution of images and only provide limited biochemical data.

Measuring the condition of grafted tissue and possible signs of cell stress following an implant or transplant, and measuring correct cell environment and growth in tissue cultures, is invaluable to the medical community. Addressing this need, the Oxford team has developed a micro membrane probe that samples soluble markers of cellular metabolism and tissue turnover both non-destructively and quantitatively within engineered tissue. The probe operates during culture periods in a bioreactor and allows for subsequent on-line and off-line analyses. The technology also has applications in meat and fish quality inspection (for contaminants such as bacterial toxins, heavy metals and pesticides).

Isis Innovation, the technology transfer company of the University of Oxford, has filed patent applications on both the new system for engineering tissue, and for the tissue probes. Isis welcomes contact from companies interested in commercialising these exciting new technologies.

Jennifer Johnson | alfa
Further information:
http://www.isis-innovation.com/licensing/1088.html

More articles from Process Engineering:

nachricht Etching Microstructures with Lasers
25.10.2016 | Fraunhofer-Institut für Lasertechnik ILT

nachricht Applying electron beams to 3-D objects
23.09.2016 | Fraunhofer-Institut für Organische Elektronik, Elektronenstrahl- und Plasmatechnik FEP

All articles from Process Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>