Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Speeding Up a Computer's Second Opinion for Breast Cancer

27.07.2006
To help computers provide faster "second opinions" on mammogram images showing suspicious-looking breast masses, medical physicists at Duke University are employing a Google-like approach that retrieves useful information from an existing mammogram database within three seconds.

Rather than comparing the mammogram image in question to every image of breast cancer in a computer database, the new approach compares the mammogram in question to selected images that are most highly ranked for their information content. This is analogous to how a Google search first returns a list of only those websites that it determines to have the most important and useful information on the words entered in the search.

In a pilot study that will be presented in August at the 48th Annual Meeting of the American Association of Physicists in Medicine in Orlando, the approach enabled computers to maintain their high level of accuracy while performing faster analysis. Such speed and efficiency will be important as such image databases rapidly grow larger and more complex.

Knowledge-based computer-assisted detection (CAD) systems compare mammogram images to those of known cases of breast cancer in order to aid radiologists in their diagnosis. However, as clinical image libraries grow rapidly in mammography practice, knowledge-based CAD systems get slower and less efficient.

In efforts to prevent such systems from bogging down, Duke's Georgia D. Tourassi, Ph.D. (Georgia.tourassi@duke.edu) will present a Knowledge-Based Computer Assisted Detection (KB-CAD) system that analyzes breast masses using the principles of information theory.

When a new, unknown case is presented for analysis, the KB-CAD system compares the case to mammography images in the database. It retrieves cases that are similar, those that share certain visual features and properties. If the unknown case is similar enough to a known case of breast cancer, then this would suggest the presence of cancer.

Although diagnostically accurate, this practice becomes inefficient as the image database increases in size. Therefore, the researchers incorporate an additional approach.

Instead of comparing the new unknown case with all mammography images stored in the knowledge database, the researchers restrict the analysis to the stored cases that are most informative. The selection of the most informative cases is done using an image indexing strategy based on the concept of "image entropy." Image entropy represents a measure of the disorder or complexity in the image. An image that is all black or white has zero entropy. An image of a checkerboard has low entropy—it consists of an equal number of light and dark pixels. Complex images with more uniform distributions of many pixel intensity levels have higher entropy and are considered more informative in the context of the Duke system.

Normal breast tissue "can be as complex as a tumor," Tourassi says. "This is precisely the reason mammographic diagnosis is such a challenging task. Our database inlcudes normal cases as well in the decision-making process."

In the recent pilot study, the Duke researchers applied their technique to a database of 2,300 mammography images. With entropy indexing, the researchers compared a sample image to the top 600 most informative, cutting down their CAD system's processing time by one-fourth, to less than 3 seconds per query. The researchers expect to launch a larger study in a year to evaluate the clinical impact of this new approach.

Meeting Paper: TU-D-330A-8, "Information-Theoretic CAD System in Mammography: Investigation of An Entropy-Based Indexing Scheme for Improved Computational Efficiency and Robust Performance," Tuesday, August 1, 2006, 2:54-3:06 PM, Room 330A. Click Here for Technical Abstract

Presented at: 48th Annual Meeting of the American Association of Physicists in Medicine, July 30-August 3, 2006, Orange County Convention Center, Orlando, FL. Click Here for Meeting Homepage

ABOUT AAPM

AAPM is a scientific, educational, and professional organization of more than 6,000 medical physicists. Headquarters are located at the American Center for Physics in College Park, MD. Publications include a scientific journal ("Medical Physics"), technical reports, and symposium proceedings.

Ben Stein | EurekAlert!
Further information:
http://www.aip.org
http://www.aapm.org

More articles from Physics and Astronomy:

nachricht Astronomers release most complete ultraviolet-light survey of nearby galaxies
18.05.2018 | NASA/Goddard Space Flight Center

nachricht A quantum entanglement between two physically separated ultra-cold atomic clouds
17.05.2018 | University of the Basque Country

All articles from Physics and Astronomy >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

Im Focus: Computer-Designed Customized Regenerative Heart Valves

Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.

Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...

Im Focus: Light-induced superconductivity under high pressure

A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.

Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Supersonic waves may help electronics beat the heat

18.05.2018 | Power and Electrical Engineering

Keeping a Close Eye on Ice Loss

18.05.2018 | Information Technology

CrowdWater: An App for Flood Research

18.05.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>