Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New high-throughput crystallization facility at EMBL-Hamburg to give boost to structural biology community

16.11.2005


Today the European Molecular Biology Laboratory (EMBL) opens a new high-throughput crystallization facility at its Outstation located on the campus of the German Synchrotron Radiation Facility (DESY) in Hamburg, Germany. The facility, made possible by major funds from the German Ministry for Science and Education (BMBF), will combine technological advances in new ways to transform proteins into crystals, a key step in efforts to automate the process of analyzing protein structures. “We’re very grateful to the BMBF and the European Union for supporting the initiative, and thus providing an important service to the European life sciences community,” says EMBL Director General Iain Mattaj.



Structural biologists attempt to understand how proteins perform their many functions by determining their three-dimensional structures by X-ray crystallography. The method has been revolutionized by the use of the most powerful sources of X-rays around the world, such as the synchrotron at DESY. EMBL offers scientists throughout Europe access to instruments at DESY and at the ESRF in Grenoble, France.

The atomic structures of biological molecules can provide key information, for example, showing how they assemble into large complexes or how their function can be inhibited by drugs. However, getting proteins into crystal form is still a major bottleneck and a time-consuming step. “It can take researchers several thousand trials to successfully crystallize a protein,” says Jochen Müller-Dieckmann, head of the new facility. But while state-of-the-art synchrotron beamlines throughout Europe are available for use by the research community, there are almost no facilities with large capacities for crystallization. That will change with the new facility in Hamburg. Even prior to the official opening, scientists have shown a keen interest.


The EMBL facility combines technological advances in new ways to automate every step along the crystallization process. With the new high-throughput set up, 10,000 experiments can be run each day, and one million experiments can be stored and imaged. After an initial test phase, the facility will serve users from all across Europe.

“The EMBL Hamburg Outstation is in a critical transition phase, building new beamlines for life sciences at the future PETRA-3 synchrotron radiation ring at DESY in Hamburg,” says EMBL-Hamburg Head Matthias Wilmanns. “The opening of the high-throughput crystallization facility is a pivotal step towards building an integrated research center with state-of-the-art facilities in structural biology.”

Sarah Sherwood | alfa
Further information:
http://www.embl.org/aboutus/news/press/2005/press16nov05.html

More articles from Physics and Astronomy:

nachricht Neutron star merger directly observed for the first time
17.10.2017 | University of Maryland

nachricht Breaking: the first light from two neutron stars merging
17.10.2017 | American Association for the Advancement of Science

All articles from Physics and Astronomy >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Ocean atmosphere rife with microbes

17.10.2017 | Life Sciences

Neutrons observe vitamin B6-dependent enzyme activity useful for drug development

17.10.2017 | Life Sciences

NASA finds newly formed tropical storm lan over open waters

17.10.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>