Today the European Molecular Biology Laboratory (EMBL) opens a new high-throughput crystallization facility at its Outstation located on the campus of the German Synchrotron Radiation Facility (DESY) in Hamburg, Germany. The facility, made possible by major funds from the German Ministry for Science and Education (BMBF), will combine technological advances in new ways to transform proteins into crystals, a key step in efforts to automate the process of analyzing protein structures. “We’re very grateful to the BMBF and the European Union for supporting the initiative, and thus providing an important service to the European life sciences community,” says EMBL Director General Iain Mattaj.
Structural biologists attempt to understand how proteins perform their many functions by determining their three-dimensional structures by X-ray crystallography. The method has been revolutionized by the use of the most powerful sources of X-rays around the world, such as the synchrotron at DESY. EMBL offers scientists throughout Europe access to instruments at DESY and at the ESRF in Grenoble, France.
The atomic structures of biological molecules can provide key information, for example, showing how they assemble into large complexes or how their function can be inhibited by drugs. However, getting proteins into crystal form is still a major bottleneck and a time-consuming step. “It can take researchers several thousand trials to successfully crystallize a protein,” says Jochen Müller-Dieckmann, head of the new facility. But while state-of-the-art synchrotron beamlines throughout Europe are available for use by the research community, there are almost no facilities with large capacities for crystallization. That will change with the new facility in Hamburg. Even prior to the official opening, scientists have shown a keen interest.
Sarah Sherwood | alfa
Further Improvement of Qubit Lifetime for Quantum Computers
09.12.2016 | Forschungszentrum Jülich
Electron highway inside crystal
09.12.2016 | Julius-Maximilians-Universität Würzburg
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
09.12.2016 | Life Sciences
09.12.2016 | Ecology, The Environment and Conservation
09.12.2016 | Health and Medicine