The new model addresses both cylindrical pores and tapering pores that simulate the á–hemolysin membrane channel. "Current models do not take into account the motion of the polymer inside the pore," says author Anatoly Kolomeisky of Rice University. "The leading monomer can move back and forth many times before it finally crosses the line to the other side of the membrane. Not accounting for this behavior introduces errors into predictions."
By improving the boundary conditions for polymer movement inside the pore, researchers demonstrated a significant increase in total time in the pore compared to earlier models. In modeling a tapering pore, they confirmed that translocation occurs faster when the polymer enters the wide side of the pore.
Possible technological applications include advances in DNA sequencing and the development of biosensors using membranes. "To design an effective sensor, it is essential to understand what you are observing and how the molecule reaches the detector," says Kolomeisky.
The article, "Polymer translocation through pores with complex geometries" by Aruna Mohan, Anatoly B. Kolomeisky, and Matteo Pasquali will be published in an upcoming issue of The Journal of Chemical Physics. See: : http://jcp.aip.org/
Journalists may request a free PDF of this article by contacting firstname.lastname@example.org
NOTE: An image is available for journalists. Please contact email@example.com
Figure Caption: "Typical Configurations of Polymer Translocation through Nanopores. Courtesy of Aruna Mohan, Rice University."ABOUT THE JOURNAL OF CHEMICAL PHYSICS
Jason Socrates Bardi | Newswise Science News
Significantly more productivity in USP lasers
06.12.2016 | Fraunhofer-Institut für Lasertechnik ILT
Shape matters when light meets atom
05.12.2016 | Centre for Quantum Technologies at the National University of Singapore
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
06.12.2016 | Materials Sciences
06.12.2016 | Medical Engineering
06.12.2016 | Power and Electrical Engineering