Researchers at the University of Wyoming discover that adding capsaicin from chili peppers to a diet can help to prevent weight gain in mice on high-fat diet
Don't go chomping on a handful of chili peppers just yet, but there may be help for hopeful dieters in those fiery little Native American fruits.
A large percentage of the world's population -- fully one third, by the World Health Organization's estimates -- is currently overweight or obese. This staggering statistics has made finding ways to address obesity a top priority for many scientists around the globe, and now a group of researchers at the University of Wyoming has found promise in the potential of capsaicin -- the chief ingredient in chili peppers -- as a diet-based supplement.
The temptation to eat fatty foods is often so strong that, for many, it can override or overpower any dietary restrictions. As a solution to this problem, a group of researchers at the University of Wyoming developed a novel approach to stimulate energy metabolism—without the need to restrict calorie intake.
During the Biophysical Society's 59th Annual Meeting in Baltimore, Md., Feb. 7-11, 2015, the researchers from the laboratory of Dr. Baskaran Thyagarajan, University of Wyoming will describe how dietary capsaicin may stimulate thermogenesis and energy burning by activating its receptors, which are expressed in white and brown fat cells. This may help to prevent and manage obesity and other related health complications such as Type 2 diabetes, high blood pressure, and cardiovascular diseases -- though this effect has not yet been demonstrated in carefully-controlled clinical trials.
"Obesity is caused by an imbalance between calorie intake and energy dissipation," explained Vivek Krishnan, a graduate student working in Baskaran Thyagarajan's laboratory at the University of Wyoming's School of Pharmacy -- a research group known as "Baskilab."
"In our bodies, white fat cells store energy and brown fat cells serve as thermogenic (heat produced by burning fat) machinery to burn stored fat. Eating calorie-rich food and a lack of physical activity cause an imbalance in metabolism that leads to obesity."
While pursuing a strategy for obesity management, our group's laboratory data revealed that "dietary capsaicin -- a chief 'agonist' (initiator of a response) of transient receptor potential vanilloid 1 (TRPV1) channel protein -- suppresses high-fat-diet-induced obesity," Krishnan said.
Baskilab has found that high-fat-diet obesity and dietary capsaicin -- 0.01 percent of capsaicin in the total high fat diet -- prevented high-fat-diet-induced weight gain in trials with wild type mice, but not in mice that genetically lacked TRPV1.
Further, dietary capsaicin didn't modify food or water intake in these mice, "although it did significantly increase the metabolic activity and energy expenditure in wild type mice fed a high-fat diet, "but not for mice that genetically lack TRPV1" Krishnan noted.
So, Baskilab's overarching hypothesis is that dietary capsaicin induces browning of white adipose tissue and stimulates thermogenesis to counteract obesity. "The main goal of our work is to expand the knowledge of the mechanism by which capsaicin antagonizes obesity, as well as to advance the proof of principle of the anti-obesity potential of dietary capsaicin. Next, we'll focus on our longer-term goal of developing TRPV1 agonists as new drug molecules to prevent and treat obesity," said researchers from Baskilab.
Developing a natural dietary supplement as a strategy to combat obesity can be easily advanced to human clinical trials, according to the researchers. "We envision a nanoparticle-based sustained-release formulation of capsaicin, which is currently under development in our laboratory," added researchers from Baskilab. "In turn, this will advance a novel dietary supplement-based approach to prevent and treat one of the life-threatening diseases, obesity and its associated complications -- in humans."
The group's strategy to counteract obesity is expected to form a major focus of future healthcare priorities for both the National Institutes of Health and Department of Defense.
Baskilab has already submitted a patent application for the drug delivery aspect of the discovery.
The poster #B399, "Dietary capsaicin and exercise: analysis of a two-pronged approach to counteract obesity" by Vivek Krishnan, Kevin Fettel and Baskaran Thyagarajan, will be in a poster session beginning at 1:45 p.m. on Sunday, February 8, 2015 in Hall C of the Baltimore Convention Center. ABSTRACT: http://tinyurl.com/kjq6tpp
ABOUT THE MEETING
Each year, the Biophysical Society Annual Meeting brings together more than 6,500 researchers working in the multidisciplinary fields representing biophysics. With more than 3,600 poster presentations, over 200 exhibits, and more than 20 symposia, the BPS Annual Meeting is the largest meeting of biophysicists in the world. Despite its size, the meeting retains its small-meeting flavor through its subgroup symposia, platform sessions, social activities and committee programs. The 59th Annual Meeting will be held at the Baltimore Convention Center.
The Biophysical Society invites professional journalists, freelance science writers and public information officers to attend its Annual Meeting free of charge. For press registration, contact Ellen Weiss at or Jason Bardi at 240-535-4954.
ABOUT THE SOCIETY
The Biophysical Society, founded in 1958, is a professional, scientific Society established to encourage development and dissemination of knowledge in biophysics. The Society promotes growth in this expanding field through its annual meeting, bi-monthly journal, and committee and outreach activities. Its 9,000 members are located throughout the U.S. and the world, where they teach and conduct research in colleges, universities, laboratories, government agencies, and industry.
For more information on the Society, or the 2015 Annual Meeting, visit http://www.biophysics.org
Jason Socrates Bardi, AIP
Jason Socrates Bardi, AIP | newswise
Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
28.04.2017 | Event News
20.04.2017 | Event News
18.04.2017 | Event News
28.04.2017 | Medical Engineering
28.04.2017 | Earth Sciences
28.04.2017 | Life Sciences