Hormone researchers at the University of Houston (UH) have their sights set on providing long-term treatment options for diabetes, obesity and cardiovascular diseases by better understanding estradiol, the most potent naturally occurring estrogen.
They now believe that this estrogen hormone is a prominent regulator of several body functions in both females and males. While estradiol is more commonly associated with processes and diseases specific to women, the team determined that the hormone actually functions as a unisex hormone with multiple actions. Research has indicated that when there is an excessive or insufficient amount of estradiol present, the metabolic network becomes imbalanced, which can result in metabolic diseases.
"Female hormones have always been associated with the menstrual cycle, pregnancy, breast-feeding and some diseases, such as osteoporosis and breast cancer, typically associated with women," said Dr. Rodrigo Barros, a research assistant professor with the UH Center for Nuclear Receptors and Cell Signaling (CNRCS). "Our group, however, has discovered that one of these hormones, estradiol, has much wider actions than previously thought. It is no longer considered exclusively a 'female sex hormone,' but a 'unisex hormone' with multiple actions across several organ systems."
Working with CNRCS director and professor Dr. Jan-Åke Gustafsson, Barros says that part of their research is dedicated to understanding how estradiol regulates feeding and food metabolism, explaining that this hormone is involved with several metabolic diseases, including eating disorders, obesity and diabetes.
"We believe that all the systems in the body involved with food consumption and metabolism, which include the brain, liver, pancreas, heart, muscles and fat, are connected by estradiol, resulting in a 'metabolic network' regulated by the hormone," Barros said. "Our evidence shows that when too much or too little estradiol is available, this delicate network loses its balance and metabolic diseases set in."
This research has important implications for the average consumer, as well as for physicians. While hormones like estradiol are important for the adequate maintenance of body functioning, they may pose serious risks to a person's health if misused as supplements. This comes into play when people use alternative forms of hormones, such as natural plant derivatives, that may be harmful if used inappropriately.
For specialists dealing with hormonal treatments, this research underscores that they should be aware that several organs and body functions are affected when estradiol is prescribed and may cause or worsen metabolic diseases. Due to the number of organs and functions affected by fluctuating levels of estradiol, its use as a hormonal treatment for patients with delayed puberty, menopausal symptoms, osteoporosis and prostate cancer is a source of debate within the medical and research communities. Exploring the impact of such treatments as reported by Barros and Gustafsson is helpful for keeping these professionals abreast of new research and guidelines.
Their findings are described in an invited review titled "Estrogen Receptors and the Metabolic Network." The report appeared in the September issue of the research journal Cell Metabolism, a high-impact monthly research journal in the Cell Press publishing network that chronicles notable research on salient scientific discoveries. To view the abstract, visit http://www.cell.com/cell-metabolism/abstract/S1550-4131%2811%2900312-3.
Funded by the Robert A. Welch Foundation, the Emerging Technology Fund of Texas and the Cancer Prevention and Research Institute of Texas, the CNRCS team works in collaboration with Sweden's Karolinska Institutet.
Editorial Note: High-resolution photos of Rodrigo Barros in the lab are available to media by contacting Lisa Merkl.
About the University of Houston
The University of Houston is a Carnegie-designated Tier One public research university recognized by The Princeton Review as one of the nation's best colleges for undergraduate education. UH serves the globally competitive Houston and Gulf Coast Region by providing world-class faculty, experiential learning and strategic industry partnerships. Located in the nation's fourth-largest city, UH serves more than 38,500 students in the most ethnically and culturally diverse region in the country.
About the College of Natural Sciences and Mathematics
The UH College of Natural Sciences and Mathematics, with 181 ranked faculty and approximately 4,500 students, offers bachelor's, master's and doctoral degrees in the natural sciences, computational sciences and mathematics. Faculty members in the departments of biology and biochemistry, chemistry, computer science, earth and atmospheric sciences, mathematics and physics conduct internationally recognized research in collaboration with industry, Texas Medical Center institutions, NASA and others worldwide.
About the UH Center for Nuclear Receptors and Cell Signaling
Established in 2009, the University of Houston Center for Nuclear Receptors and Cell Signaling (CNRCS) is the centerpiece of the university's tier-one biomedical research initiative and member of the internationally renowned Texas Medical Center. Working from the center's state-of-the-art labs, CNRCS researchers combine interdisciplinary research with dynamic collaboration within the medical center and with industry partners, with the goal of finding new treatments for an array of significant diseases, including cancer, diabetes and metabolic syndrome. To learn more, visit http://cnrcs.uh.edu.
For more information about UH, visit the university's Newsroom at http://www.uh.edu/news-events/.
To receive UH science news via e-mail, sign up for UH-SciNews at http://www.uh.edu/news-events/mailing-lists/sciencelistserv/index.php.
For additional news alerts about UH, follow us on Facebook at http://www.facebook.com/UHNewsEvents and Twitter at http://twitter.com/UH_News.
Lisa Merkl | EurekAlert!
Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München
Second cause of hidden hearing loss identified
20.02.2017 | Michigan Medicine - University of Michigan
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
22.02.2017 | Power and Electrical Engineering
22.02.2017 | Life Sciences
22.02.2017 | Physics and Astronomy