In an original paper, just published in the interdisciplinary medical e-Journal "GMS German Medical Science" of the Association of the Scientific Medical Societies in Germany (AWMF), the beneficial effects of wIRA in chronic venous stasis ulcers could be demonstrated by clinical assessments and as well by extensive thermographic investigations.
It is estimated that at least 1% of the population in industrialised countries will suffer from leg ulcer at some time. A prospective study of the University Tromsø/Norway and the Hospital in Hillerød/Denmark of 10 patients with non-healing chronic venous stasis ulcers of the lower legs, in which other therapies were not successful, resulted under therapy with wIRA in a complete or almost complete wound healing (96-100% reduction of wound area) in 7 of 10 patients and a reduction of the ulcer size in another 2 of 10 patients. The uncovered wounds of the patients were irradiated two to five times per week for 30 minutes. Treatment continued for a period of up to 2 months (typically until closure or nearly closure of the ulcer was achieved).
An example of a successful course of therapy with wIRA irradiation is demonstrated in Figure 1 with normal view, thermographic image and temperature profile across the ulcer, in each case before therapy and after completion of therapy.
Among the 6 patients without concomitant problems (peripheral occlusive arterial disease, smoking or lacking compression garment therapy) a complete or almost complete wound healing was achieved without any exception. Even in the 4 patients with concomitant problems clear reductions of wound area were reached in 4 of the 5 ulcers including one complete wound closure. In one patient a randomized controlled side comparison was possible (therapy of one leg with an ulcer with wIRA and visible light, therapy of the other leg with another ulcer with a control group radiator, emitting only visible light without wIRA) and revealed marked differences in favour of wIRA.
In addition the study showed under therapy with wIRA a clear reduction of pain and required pain medication (e.g. from 15 to 0 pain tablets per day) and a normalization of the thermographic image. Prior to the start of therapy typically the rim of the ulcer was hyperthermic, accompanied with a relative hypothermic ulcer base, partly associated with up to 4.5°C temperature gradiance. At the end of the course of therapy the temperature differences were mostly balanced. All assessments using visual analogue scales (VAS: pain sensation of the patient in the wound area, overall rating of the effect of the irradiation by the patient and by the clinical investigator, overall assessment of the feeling of the patient of the wound area, overall evaluation of the wound healing process by the clinical investigator, overall assessment of the cosmetic appearance by the patient and by the clinical investigator) improved remarkably during the period of irradiation therapy and commensurated with the improvement of the quality of life.
Wound healing and infection defence depend decisively on a sufficient supply with energy and oxygen. The central portion of chronic wounds is often clearly hypoxic and relatively hypothermic - as thermographically shown in the study -, representing a deficient energy supply of the tissue, which impedes wound healing or even makes it impossible. wIRA produces a therapeutically usable field of heat in the tissue and increases tissue temperature, tissue oxygen partial pressure, and tissue perfusion. These three factors are vital for a sufficient tissue supply with energy and oxygen. The good clinical effect of wIRA on wounds and wound infections can be explained by the improvement of both the energy supply per time (increase of metabolic rate) and the oxygen supply. In addition wIRA has non-thermal and non-thermic effects, which are based on putting direct stimuli on cells and cellular structures.
Publication:Mercer JB, Nielsen SP, Hoffmann G. Improvement of wound healing by water-filtered infrared-A (wIRA) in patients with chronic venous stasis ulcers of the lower legs including evaluation using infrared thermography. GMS Ger Med Sci. 2008;6:Doc11.
The freely available publication includes 10 patient appendices and 2 video sequences.
Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania
The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.
The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...
UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration
"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...
Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.
Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...
10.01.2017 | Event News
09.01.2017 | Event News
05.01.2017 | Event News
16.01.2017 | Power and Electrical Engineering
16.01.2017 | Information Technology
16.01.2017 | Power and Electrical Engineering