Highlights of Prof. Hayakawa's research who is currently developing methods to identify metabolites of PAHs and NPAHs in urine and blood. Other work include developing the most sensitive method for measuring PAHs and NPAHs, showing that motorcycle engines released more particulate matter than automobiles and more
A leading professor has spent his considerable career at Kanazawa University in Japan investigating the toxic by-products of burning fuels, and the associated impacts on human health.
Toxic (nitro)polycyclic aromatic hydrocarbons (PAHs/NPAHs), the by-products from burning fuels such as diesel, are now known to have a significant impact on human health. Current understanding of the nature and effects of these molecules has been greatly enhanced by the work of Kazuichi Hayakawa at Kanazawa University, Japan.
Polycyclic aromatic hydrocarbons (PAHs) and their related molecules, nitropolycyclic aromatic hydrocarbons (NPAHs), are released when fuel – either fossil fuels or biomass – is burnt. They are also present following tobacco and fat combustion. PAHs and NPAHs are known to be highly carcinogenic and mutagenic, meaning they can trigger genetic mutations in living organisms. The impact of these particular molecules on human health is now being uncovered, thanks in no small part to the work of Kazuichi Hayakawa at Kanazawa University. The research is featured in the May issue of the Kanazawa University Research Bulletin: http://www.kanazawa-u.ac.jp/research_bulletin/index.html
Hayakawa is highly regarded for his development of an extremely sensitive method of determining NPAH / PAH concentrations in atmospheric particulate samples. His technique uses high performance liquid chromatography with chemiluminescence detection – separating out the chemical components of particulate matter and classifying them according to how they emit light and heat (1).
“In the 1970s, there was no analytical method for monitoring trace levels of atmospheric NPAHs, even though the toxicity of NPAHs was very strong,” explains Hayakawa. “My analytical method for determining both PAH and NPAH levels, developed over 20 years ago, remains the most sensitive technique to date.”
Hayakawa discovered that the NPAH/PAH concentration ratio in any given sample is dependent upon the original combustion temperature of the fuel. In this way, airborne particulate samples can be analyzed and the original source of the pollutants can be identified – for example burning coal, diesel or petrol.
Between 1997 and 2002, Hayakawa led a study of airborne particulates in seven cities across East Asia2. The research revealed that, due to the higher combustion temperature, diesel engine vehicles in Japan released far more PAHs/NPAHs into the atmosphere than coal heating systems, which were predominant in China.
In 2013, novel research published by Hayakawa and his team illustrates that motorcycle engines release more particulate matter and higher levels of PAHs than automobile engines (3). The same paper shows that motorcycle particulates hold stronger PAH-related mutagenicity than emissions from other vehicles.
As well as studying atmospheric PAHs/NPAHs over recent decades, Hayakawa has been involved in numerous investigations into the effects of these molecules on human health. His team found that NPAHs originating from diesel fuels were implicated in the development of cancerous tissues in the body (4).
Furthermore, in research published in 2003, they uncovered the role of diesel fuel PAHs in disrupting the testosterone and estrogen effects in men and women, respectively, a condition which can lead to prostate cancer and genetic reproductive disorders5.
“I am currently developing methods to identify metabolites of PAHs and NPAHs in biological samples such as urine and blood,” describes Hayakawa. “These methods will determine the risk of exposure to PAHs and NPAHs.”
Kazuichi Hayakawa’s research will continue to provide insight into environmental pollution across the globe. It will also inform the development of countermeasures that should help to reduce human health risks.
Organization of Frontier Science and Innovation, Kanazawa University
Kakuma, Kanazawa, Ishikawa 920-1192, Japan
About Kanazawa University
Kanazawa University, Japan publishes the May 2014 issue of its online newsletter, Kanazawa University Research Bulletin: http://www.kanazawa-u.ac.jp/research_bulletin/index.html
Kanazawa University Research Bulletin highlights the latest research from one of Japan's leading comprehensive universities with its three colleges and 16 schools offering courses in subjects that include medicine, computer engineering, and humanities.
As the leading comprehensive university on the Sea of Japan coast, Kanazawa University has contributed greatly to higher education and academic research in Japan since it was founded in 1949. The University has three colleges and 16 schools offering courses in subjects that include medicine, computer engineering, and humanities.
The University is located on the coast of the Sea of Japan in Kanazawa—a city rich in history and culture. The city of Kanazawa has cultivated a highly respected intellectual profile since the time of the Kaga fiefdom (1598–1867). Kanazawa University is divided into two main campuses: Kakuma and Takaramachi for its approximately 12,200 students including 500 from overseas.
Kanazawa University website: http://www.kanazawa-u.ac.jp/e/index.html
1. K. Hayakawa et al. Determination of 1,3-, 1,6- and 1,8- dinitropyrenes and 1-nitropyrene in urban air by high-performance liquid chromatography using chemiluminescence detection. Environmental Science and Technology 29 (4) (1995)
2. N. Tang et al. Polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons in urban air particulates and their relationship to emission sources in the Pan–Japan sea countries. Atmospheric Environment 39 (2005)
3. C.T. Pham et al. Polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons in particulates emitted by motorcycles. Environmental Pollution 183 (2013)
4. M. Iwanari et al. Induction of CYP1A1, CYP1A2, and CYP1B1 mRNAs by nitropolycyclic aromatic hydrocarbons in various human tissue-derived cells: chemical-, cytochrome P450 isoform-, and cell-specific differences. Arch Toxicology 76 (2002)
5. R. Kizu et al. A role of aryl hydrocarbon receptor in the antiandrogenic effects of polycyclic aromatic hydrocarbons in LNCaP human prostate carcinoma cells. Arch Toxicology 77 (2003)
*corresponding author, e-mail address: firstname.lastname@example.org
An ounce of prevention: Research advances on 'scourge' of transplant wards
28.08.2015 | University of Wisconsin-Madison
Hypoallergenic parks: Coming soon?
27.08.2015 | American Society of Agronomy
A University of Oklahoma astrophysicist and his Chinese collaborator have found two supermassive black holes in Markarian 231, the nearest quasar to Earth, using observations from NASA's Hubble Space Telescope.
The discovery of two supermassive black holes--one larger one and a second, smaller one--are evidence of a binary black hole and suggests that supermassive...
A team of European researchers have developed a model to simulate the impact of tsunamis generated by earthquakes and applied it to the Eastern Mediterranean. The results show how tsunami waves could hit and inundate coastal areas in southern Italy and Greece. The study is published today (27 August) in Ocean Science, an open access journal of the European Geosciences Union (EGU).
Though not as frequent as in the Pacific and Indian oceans, tsunamis also occur in the Mediterranean, mainly due to earthquakes generated when the African...
In mountainous regions earthquakes often cause strong landslides, which can be exacerbated by heavy rain. However, after an initial increase, the frequency of these mass wasting events, often enormous and dangerous, declines, in fact independently of meteorological events and aftershocks.
These new findings are presented by a German-Franco-Japanese team of geoscientists in the current issue of the journal Geology, under the lead of the GFZ...
Bacteria do not cease to amaze us with their survival strategies. A research team from the University of Basel's Biozentrum has now discovered how bacteria enter a sleep mode using a so-called FIC toxin. In the current issue of “Cell Reports”, the scientists describe the mechanism of action and also explain why their discovery provides new insights into the evolution of pathogens.
For many poisons there are antidotes which neutralize their toxic effect. Toxin-antitoxin systems in bacteria work in a similar manner: As long as a cell...
It comes when called, bringing care utensils with it and recording how they are used: Fraunhofer IPA is developing an intelligent care cart that provides care staff with physical and informational support in their day-to-day work. The scientists at Fraunhofer IPA have now completed a first prototype. In doing so, they are continuing in their efforts to improve working conditions in the care sector and are developing solutions designed to address the challenges of demographic change.
Technical assistance systems can improve the difficult working conditions in residential nursing homes and hospitals by helping the staff in their work and...
20.08.2015 | Event News
20.08.2015 | Event News
19.08.2015 | Event News
28.08.2015 | Physics and Astronomy
28.08.2015 | Health and Medicine
28.08.2015 | Life Sciences