Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Testosterone deficiency in childhood cancer survivors

04.06.2010
Almost a quarter of men treated for cancer in their childhood suffer from a deficiency of the male sex hormone testosterone. The deficiency can be treated with hormone supplements if the problem is diagnosed. However, this happens all too rarely, as doctor Patrik Romerius shows in his thesis, Lund University in Sweden.

Testosterone deficiency not only affects sex drive: in the long term it can lead to depression, reduced muscle strength, osteoporosis, type 2 diabetes, high blood pressure and cardiovascular diseases.

“But if a young man comes to the health centre and complains of low libido and depression, this might be explained as the psychological effects of the cancer he had when he was younger. In actual fact it may be due to a hormone reduction that can be treated”, says Patrik Romerius.

In one of his studies he examined 150 men who had been treated for leukaemia and other forms of cancer before reaching adulthood. He found that 33 of them had testosterone deficiency, but that this had only been diagnosed in 4 cases. Patrik Romerius believes that the reason for this is that it is a new patient group.

“Just a few decades ago, very few childhood cancer patients survived. Now almost 4 in 5 recover as a result of better diagnosis and treatment methods. But it is only now that the large groups of childhood cancer survivors have reached an age where the consequences of the treatment are starting to be seen”, he says.

The majority of the former cancer patients who were suffering from hormone deficiency were also infertile because the cancer treatment had impaired their sperm production. During and after puberty, young men can provide sperm samples that are frozen and saved, but before puberty, boys do not produce sperm. The only option then is to remove testicular tissue to be preserved for the future. Today it is not possible to extract sperm from such tissue, but this has been achieved in animal experiments and could become possible in humans in the future.

However, removing testicular tissue involves a separate operation before the actual cancer treatment – a further strain for the young cancer patient. The research group has produced a genetic marker that makes it possible, by means of a simple blood test, to identify which patients are at highest risk of losing their sperm production entirely and should therefore be offered the operation.

Patrik Romerius can be contacted by telephone, +46 (0)735 308 108, or email, patrik.romerius@med.lu.se.

Pressofficer Ingela Björck; ingela.bjorck@rektor.lu.se +46-46 222 7646

The articles in the thesis have been published in the Journal of Clinical Endocrinology and Metabolism 2009, the International Journal of Andrology 2010 (published online ahead of print) and Clinical Cancer Research 2010 (in press).

Ingela Björck | idw
Further information:
http://www.lu.se/o.o.i.s?id=12588&postid=1600624

More articles from Health and Medicine:

nachricht World first: Massive thrombosis removed during early pregnancy
20.07.2017 | Universitätsspital Bern

nachricht Therapy of preterm birth in sight?
19.07.2017 | Universitätsspital Bern

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

Im Focus: Laser-cooled ions contribute to better understanding of friction

Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision

Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

NASA looks to solar eclipse to help understand Earth's energy system

21.07.2017 | Earth Sciences

Stanford researchers develop a new type of soft, growing robot

21.07.2017 | Power and Electrical Engineering

Vortex photons from electrons in circular motion

21.07.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>