Liwei Chen, MD, PhD, Assistant Professor of Epidemiology at LSU Health Sciences Center New Orleans School of Public Health, is the lead author of the paper, A Prospective Study of Pre-Gravid Sugar-Sweetened Beverage Consumption and the Risk of Gestational Diabetes Mellitus, that will be published in the December 2009 issue of Diabetes Care and is available online now at http://diabetes.org/diabetescare.
The research team studied a group of 13,475 women from the Nurses' Health Study II. During 10 years of follow-up, 860 incident GDM cases were identified. After adjustment for known risk factors for GDM including age, family history of diabetes, parity, physical activity, smoking status, sugar-sweetened beverage intake, alcohol intake, prepregnancy BMI, and Western dietary pattern, intake of sugar-sweetened cola was positively associated with the risk of GDM. No significant association was found for other sugar-sweetened beverages or diet beverages.
"Compared with women who consumed less than 1 serving per month, those who consumed more than 5 servings per week of sugar-sweetened cola had a 22% greater GDM risk," notes Dr. Chen.
Gestational diabetes mellitus (GDM), defined as glucose intolerance beginning during pregnancy, is one of the most common pregnancy complications. Women with GDM are at increased risk for complications and illness during pregnancy and delivery, as well as post-pregnancy type 2 diabetes. Children of mothers with GDM are at increased risk for obesity, glucose intolerance, and early onset diabetes.
Although the underlying mechanism remains unclear, available evidence suggests that the main defect in the development of GDM is relatively diminished insulin secretion coupled with pregnancy-induced insulin resistance. The researchers discuss a number of explanations of their findings. Consuming a large amount of sugar-sweetened beverages could contribute to a high glycemic load (GL) by providing a large amount of rapidly absorbable sugars. High-GL foods induce a greater plasma glucose response after eating which can result in insulin resistance and impaired beta cell function. (Pancreatic beta cells make insulin.) In addition, higher sugar intake itself may lead to impaired pancreatic cell function.
"We don't know why significant association was only found in sugar-sweetened cola, but not other types of sugar-sweetened beverages – fruit drinks, other soft drinks, etc.," says Dr. Chen. "One of the explanations could be the tremendous popularity of cola in the US."
Previous studies in children and adults have shown that regular consumption of sugary drinks is associated with excess caloric intake, greater weight gain, and increased risk of obesity. Sugary drinks have also been linked to type 2 diabetes and other metabolic disorders.
"This is the first study on the impact of sugar-sweetened beverages on GDM risk," notes Dr. Chen. "This finding is important because sugar-sweetened beverages are the leading source of added sugars in the American diet, particularly in the age group most likely to conceive. Cutting down sugary drinks is clearly an important way to reduce this common pregnancy complication."
According to the National Health and Nutrition Examination Survey 1999-2001, from 1977 to 2001, soft drink intake increased from 4.1% to 9.8% for 19- to 39-year-olds. In percentage terms, soft drink intake was highest among this age group in comparison to other ages.
This study was supported by the National Institutes of Health and part of the work was done when Dr. Chen received an Intramural Research Training Award Fellowship under Dr. Cuilin Zhang (senior author) at the Division of Epidemiology, Statistics, and Prevention Research at the NICHD.
LSU Health Sciences Center New Orleans educates Louisiana's health care professionals. The state's academic health leader, LSUHSC comprises a School of Medicine, the state's only School of Dentistry, Louisiana's only public School of Public Health, and Schools of Allied Health Professions, Nursing, and Graduate Studies. LSUHSC faculty take care of patients in public and private hospitals and clinics throughout the region. In the vanguard of biosciences research in a number of areas in a worldwide arena, the LSUHSC research enterprise generates jobs and enormous economic impact, LSUHSC faculty have made lifesaving discoveries and continue to work to prevent, advance treatment, or cure disease.
Routing gene therapy directly into the brain
07.12.2017 | Boston Children's Hospital
New Hope for Cancer Therapies: Targeted Monitoring may help Improve Tumor Treatment
01.12.2017 | Berliner Institut für Gesundheitsforschung / Berlin Institute of Health (BIH)
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications
Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...
Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.
The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...
Transistors based on carbon nanostructures: what sounds like a futuristic dream could be reality in just a few years' time. An international research team working with Empa has now succeeded in producing nanotransistors from graphene ribbons that are only a few atoms wide, as reported in the current issue of the trade journal "Nature Communications."
Graphene ribbons that are only a few atoms wide, so-called graphene nanoribbons, have special electrical properties that make them promising candidates for the...
08.12.2017 | Event News
07.12.2017 | Event News
05.12.2017 | Event News
08.12.2017 | Life Sciences
08.12.2017 | Information Technology
08.12.2017 | Information Technology