Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Stem cells to treat lung disease in preterm infants

06.02.2014
Advances in neonatal care for very preterm infants have greatly increased the chances of survival for these fragile infants.

However, preterm infants have an increased risk of developing bronchopulmonary dysplasia (BPD), a serious lung disease, which is a major cause of death and lifelong complications.

In a new study scheduled for publication in The Journal of Pediatrics, researchers evaluated the safety and feasibility of using stem cell therapies on very preterm infants to prevent or treat BPD.

Won Soon Park, MD, PhD, and colleagues from Samsung Medical Center and Biomedical Research Institute, Seoul, Republic of Korea, conducted a phase I, single-center trial of intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells to nine very preterm infants (24-26 weeks gestational age) who were at high risk of developing BPD.

All patients who received the treatment tolerated the procedure well without any immediate serious adverse effects. Thirty-three percent of treated infants developed moderate BPD and none developed severe BPD, and 72 percent of a matched comparison group developed moderate or severe BPD.

Another serious side effect of very preterm birth, retinopathy of prematurity requiring surgery, tended to occur less often in treated infants. Overall, all nine treated infants survived to discharge, and only three developed moderate BPD.

This phase I study suggests that intratracheal administration of mesenchymal stem cells is safe and feasible. According to Dr. Park, "These findings strongly suggest that phase II clinical trials are warranted to test the efficacy of mesencymal stem cell transplantation, which could lead to new therapies to prevent or cure BPD." Dr. Park and colleagues are currently conducting a long-term safety and follow-up study of these nine preterm infants (ClinicalTrials.gov: NCT01632475).

Becky Lindeman | EurekAlert!
Further information:
http://www.us.elsevierhealth.com

More articles from Health and Medicine:

nachricht Some Anti-Inflammatory Drugs Affect More Than Their Targets
22.08.2014 | Johns Hopkins Medicine

nachricht Pain treatments less effective for those with irritable bowel
21.08.2014 | University of Adelaide

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

MEDICA EDUCATION CONFERENCE: Bessere Behandlung dank Biomarker

21.08.2014 | Event News

Mathematics and Computer Science - Key Disciplines in Developing Countries as well?

20.08.2014 | Event News

5th Technical Conference "Subsoil Analysis, Ground Improvement and Wind Turbine Foundations"

13.08.2014 | Event News

 
Latest News

Yale's cool molecules

22.08.2014 | Physics and Astronomy

Fungus deadly to AIDS patients found to grow on trees

22.08.2014 | Life Sciences

Novel recycling methods: The fluorescent fingerprint of plastics

22.08.2014 | Ecology, The Environment and Conservation

VideoLinks
B2B-VideoLinks
More VideoLinks >>>